Evaluation of immunotoxicity of shizukaol B isolated from Chloranthus japonicus

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dc.contributor.authorS W Kwon-
dc.contributor.authorYoung Kook Kim-
dc.contributor.authorJ Y Kim-
dc.contributor.authorH S Ryu-
dc.contributor.authorH K Lee-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorHwan Mook Kim-
dc.contributor.authorJ T Hong-
dc.contributor.authorY Kim-
dc.contributor.authorS B Han-
dc.date.accessioned2017-04-19T09:22:02Z-
dc.date.available2017-04-19T09:22:02Z-
dc.date.issued2011-
dc.identifier.issn1976-9148-
dc.identifier.uri10.4062/biomolther.2011.19.1.059ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10008-
dc.description.abstractDimeric sesquiterpenoid shizukaol B (SKB) was isolated from Chloranthus japonicus Sieb. Except that SKB inhibited adhesion molecule expression in monocytes and endothelial cells, no more biological and pharmacological activity of SKB had been reported until now. In this study, we examined immunosuppressive activity of SKB. SKB strongly inhibited lipopolysaccharide (LPS)- induced B cell proliferation with IC50 of 137 ng/ml, but slightly or not concanavalin A-induced T cell proliferation, LPS-induced macrophage NO production, and LPS-induced dendritic cell maturation. As a mechanism, SKB strongly induced apoptotic death of B cells, but not other cell types. These results suggested that SKB induced toxicity-mediated immunosuppression against B cells.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleEvaluation of immunotoxicity of shizukaol B isolated from Chloranthus japonicus-
dc.title.alternativeEvaluation of immunotoxicity of shizukaol B isolated from Chloranthus japonicus-
dc.typeArticle-
dc.citation.titleBiomolecules & Therapeutics-
dc.citation.number1-
dc.citation.endPage64-
dc.citation.startPage59-
dc.citation.volume19-
dc.contributor.affiliatedAuthorYoung Kook Kim-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.alternativeName권순우-
dc.contributor.alternativeName김영국-
dc.contributor.alternativeName김지연-
dc.contributor.alternativeName류화순-
dc.contributor.alternativeName이홍경-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName홍진태-
dc.contributor.alternativeName김영수-
dc.contributor.alternativeName한상배-
dc.identifier.bibliographicCitationBiomolecules & Therapeutics, vol. 19, no. 1, pp. 59-64-
dc.identifier.doi10.4062/biomolther.2011.19.1.059-
dc.subject.keywordB cells-
dc.subject.keywordChloranthus japonicus-
dc.subject.keywordCytotoxicity-
dc.subject.keywordImmunosuppression-
dc.subject.keywordShizukaol B-
dc.subject.localB cell-
dc.subject.localB cells-
dc.subject.localChloranthus japonicus-
dc.subject.localchloranthus japonicus-
dc.subject.localCytotoxicity-
dc.subject.localcytotoxicity-
dc.subject.localImmunosuppression-
dc.subject.localimmunosuppression-
dc.subject.localShizukaol B-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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