DC Field | Value | Language |
---|---|---|
dc.contributor.author | P Khiev | - |
dc.contributor.author | Sei Ryang Oh | - |
dc.contributor.author | Hee Sung Chae | - |
dc.contributor.author | Ok-Kyoung Kwon | - |
dc.contributor.author | Kyung Seop Ahn | - |
dc.contributor.author | Y W Chin | - |
dc.contributor.author | Hyeong Kyu Lee | - |
dc.date.accessioned | 2017-04-19T09:22:03Z | - |
dc.date.available | 2017-04-19T09:22:03Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0009-2363 | - |
dc.identifier.uri | 10.1248/cpb.59.382 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10009 | - |
dc.description.abstract | Bioactivity-guided isolation on a n-hexane-soluble fraction of Thyrsanthera suborbicularis led to the isolation of a new rosane-type diterpene, 19-hydroxy-1(10), 15-rosadiene (1), along with three known compounds, taraxerol, acetyl aleuritolic acid, and spathulenol. The structures of isolated compounds were determined by interpretation of NMR spectroscopic data and mass spectrometry. Compound 1 demonstrated significantly inhibitory activity on nitric oxide production in RAW264.7 lipopolysaccharide (LPS)-activated mouse macrophages with an IC50 value of 2.91 μg/ml via the suppression of inducible nitric oxide synthase (iNOS) mRNA expression. | - |
dc.publisher | Pharmaceutical Soc Japan | - |
dc.title | Anti-inflammatory diterpene from Thyrsanthera suborbicularis | - |
dc.title.alternative | Anti-inflammatory diterpene from Thyrsanthera suborbicularis | - |
dc.type | Article | - |
dc.citation.title | Chemical & Pharmaceutical Bulletin | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 384 | - |
dc.citation.startPage | 382 | - |
dc.citation.volume | 59 | - |
dc.contributor.affiliatedAuthor | Sei Ryang Oh | - |
dc.contributor.affiliatedAuthor | Hee Sung Chae | - |
dc.contributor.affiliatedAuthor | Ok-Kyoung Kwon | - |
dc.contributor.affiliatedAuthor | Kyung Seop Ahn | - |
dc.contributor.affiliatedAuthor | Hyeong Kyu Lee | - |
dc.contributor.alternativeName | Khiev | - |
dc.contributor.alternativeName | 오세량 | - |
dc.contributor.alternativeName | 채희성 | - |
dc.contributor.alternativeName | 권옥경 | - |
dc.contributor.alternativeName | 안경섭 | - |
dc.contributor.alternativeName | 진영원 | - |
dc.contributor.alternativeName | 이형규 | - |
dc.identifier.bibliographicCitation | Chemical & Pharmaceutical Bulletin, vol. 59, no. 3, pp. 382-384 | - |
dc.identifier.doi | 10.1248/cpb.59.382 | - |
dc.subject.keyword | Euphorbiaceae | - |
dc.subject.keyword | Inducible nitric oxide synthase | - |
dc.subject.keyword | Nitric oxide | - |
dc.subject.keyword | Rosane diterpenoid | - |
dc.subject.keyword | Thyrsanthera suborbicularis | - |
dc.subject.local | euphorbiaceae | - |
dc.subject.local | Euphorbiaceae | - |
dc.subject.local | Inducible nitric oxide synthase (iNOS) | - |
dc.subject.local | Inducible nitric oxide synthase | - |
dc.subject.local | inducible nnitric oxide synthase | - |
dc.subject.local | iNOS | - |
dc.subject.local | Inducible nitric oxide synthease (iNOS) | - |
dc.subject.local | INOS | - |
dc.subject.local | inducible nitric oxide synthase | - |
dc.subject.local | NO | - |
dc.subject.local | nitric oxide | - |
dc.subject.local | nitric oxide (NO) | - |
dc.subject.local | Nitric oxide | - |
dc.subject.local | NO (Nitric oxide) | - |
dc.subject.local | nitric oxide. | - |
dc.subject.local | Nitric oxid | - |
dc.subject.local | Nitric oxide (NO) | - |
dc.subject.local | Rosane diterpenoid | - |
dc.subject.local | Thyrsanthera suborbicularis | - |
dc.description.journalClass | Y | - |
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