Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus

Cited 20 time in scopus
Metadata Downloads
Title
Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus
Author(s)
J W Cho; Yun-Ju Kwon; Mi Jin Sohn; S J Seok; Won Gon Kim
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 6, pp. 1716-1718
Publication Year
2011
Abstract
A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC50 of 6 μM and also showed antibacterial activity against S. aureus and MRSA.
Keyword
AntibacterialEnoyl-ACP reductaseHispidinInhibitorPhellinus linteusStaphylococcus aureus
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2011.01.080
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.