DC Field | Value | Language |
---|---|---|
dc.contributor.author | H S Kim | - |
dc.contributor.author | J Hwang | - |
dc.contributor.author | Y H Kim | - |
dc.contributor.author | S Kim | - |
dc.contributor.author | J W Lee | - |
dc.contributor.author | H S Kang | - |
dc.contributor.author | K S Kim | - |
dc.contributor.author | J H Ha | - |
dc.contributor.author | J W Chung | - |
dc.contributor.author | Kyu Tae Chang | - |
dc.contributor.author | Z Y Ryoo | - |
dc.contributor.author | S Lee | - |
dc.date.accessioned | 2017-04-19T09:22:05Z | - |
dc.date.available | 2017-04-19T09:22:05Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0026-8925 | - |
dc.identifier.uri | 10.1007/s00438-009-0469-z | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10021 | - |
dc.description.abstract | Gene expression profiles of hematopoietic stem cells (HSCs) provide clues for understanding molecular mechanisms of HSC behavior, including self-renewal and differentiation. We took advantage of serial analysis of gene expression (SAGE) to identify medium- and low-abundant transcripts expressed in HSCs/hematopoietic progenitor cells (HPCs). Among a total of 31,380 unique transcripts, 17,326 (55%) correspond to known genes and, 14,054 (45%) are low-copy transcripts that have no matches to currently known genes. Among the former class, 3,899 (23%) were alternatively spliced transcripts and 3,754 (22%) represent anti-sense transcripts from known genes. Mapping of the SAGE tags to the mouse genome showed that differences in gene expression exist among chromosomes. In addition, comparison of the HSCs/HPCs SAGE data to that of myeloid progenitor cells revealed that massive genetic reprogramming occurs in hematopoietic cell differentiation. Our results demonstrate a previously unrecognized complexity of gene expression in HSCs/HPCs, and indicate the need for further efforts to fully identify and characterize the transcripts expressed in this cell type. | - |
dc.publisher | Springer | - |
dc.title | Detection of low-abundant novel transcripts in mouse hematopoietic stem cells | - |
dc.title.alternative | Detection of low-abundant novel transcripts in mouse hematopoietic stem cells | - |
dc.type | Article | - |
dc.citation.title | Molecular Genetics and Genomics | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 370 | - |
dc.citation.startPage | 363 | - |
dc.citation.volume | 282 | - |
dc.contributor.affiliatedAuthor | Kyu Tae Chang | - |
dc.contributor.alternativeName | 김형수 | - |
dc.contributor.alternativeName | 황준모 | - |
dc.contributor.alternativeName | 김영훈 | - |
dc.contributor.alternativeName | 김성건 | - |
dc.contributor.alternativeName | 이재웅 | - |
dc.contributor.alternativeName | 강형식 | - |
dc.contributor.alternativeName | 김길수 | - |
dc.contributor.alternativeName | 하지홍 | - |
dc.contributor.alternativeName | 정진웅 | - |
dc.contributor.alternativeName | 장규태 | - |
dc.contributor.alternativeName | 류재영 | - |
dc.contributor.alternativeName | 이상규 | - |
dc.identifier.bibliographicCitation | Molecular Genetics and Genomics, vol. 282, no. 4, pp. 363-370 | - |
dc.identifier.doi | 10.1007/s00438-009-0469-z | - |
dc.subject.keyword | Gene expression | - |
dc.subject.keyword | Gr-1 myeloid progenitor cell | - |
dc.subject.keyword | Hematopoietic stem cell | - |
dc.subject.keyword | SAGE | - |
dc.subject.keyword | Transcriptome | - |
dc.subject.local | Gene Expression | - |
dc.subject.local | Gene expression | - |
dc.subject.local | gene expression | - |
dc.subject.local | Gr-1 myeloid progenitor cell | - |
dc.subject.local | Hematopoietic stem cell | - |
dc.subject.local | hematopoietic stem cell | - |
dc.subject.local | Hematopoietic stem cells | - |
dc.subject.local | SAGE | - |
dc.subject.local | Transcriptomes | - |
dc.subject.local | transcriptome | - |
dc.subject.local | Transcriptome | - |
dc.description.journalClass | Y | - |
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