A Phellinus baumii extract reduces obesity in high-fat diet-fed mice and absorption of triglyceride in lipid-loaded mice

Cited 20 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJung-Ran Noh-
dc.contributor.authorI K Lee-
dc.contributor.authorS Y Ly-
dc.contributor.authorK J Yang-
dc.contributor.authorGil-Tae Gang-
dc.contributor.authorYong Hoon Kim-
dc.contributor.authorJung Hwan Hwang-
dc.contributor.authorB S Yun-
dc.contributor.authorChul Ho Lee-
dc.date.accessioned2017-04-19T09:22:05Z-
dc.date.available2017-04-19T09:22:05Z-
dc.date.issued2011-
dc.identifier.issn1096-620X-
dc.identifier.uri10.1089/jmf.2010.1152ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10023-
dc.description.abstractThis study evaluated the anti-obesity effects of Phellinus baumii extract (PBE) in high-fat diet (HFD)-fed mice. Male 8-week-old C57BL/6 mice were randomly divided into four groups: control, normal chow diet plus vehicle; HFD-control, high-fat plus vehicle; HFD plus orlistat (Xenical®, Roche, Basel, Switzerland) (50 mg/kg); and HFD plus PBE (500 mg/kg). PBE was administered daily by oral gavage for 12 weeks. Oral administration of PBE (500 mg/kg) significantly reduced body weight gain, hepatic lipid concentrations, and fat accumulation in epididymal adipocytes compared with mice fed HFD alone (P < .05). mRNA expression of genes related to triglyceride (TG) synthesis was suppressed in the PBE groups, and fatty acid synthase activity was also significantly inhibited (P < .05). Furthermore, we evaluated the effect of PBE on TG absorption and detected marked reduction in TG absorption in Xenical- and PBE-treated mice compared with the control group (P < .05). To determine the active compound of PBE, fractionation was conducted, and interfungin A, davallialactone, and hypholomine B were identified as the main compounds. Among the three identified compounds, as a representative compound, davallialactone was also shown to suppress fat accumulation in an in vitro model system. These anti-obesity and hypolipidemic effects appear to be partly mediated by suppressing plasma and hepatic fat accumulation through the inhibition of enzymes associated with hepatic and intestinal lipid absorption and synthesis.-
dc.publisherMary Ann Liebert, Inc-
dc.titleA Phellinus baumii extract reduces obesity in high-fat diet-fed mice and absorption of triglyceride in lipid-loaded mice-
dc.title.alternativeA Phellinus baumii extract reduces obesity in high-fat diet-fed mice and absorption of triglyceride in lipid-loaded mice-
dc.typeArticle-
dc.citation.titleJournal of Medicinal Food-
dc.citation.number3-
dc.citation.endPage218-
dc.citation.startPage209-
dc.citation.volume14-
dc.contributor.affiliatedAuthorJung-Ran Noh-
dc.contributor.affiliatedAuthorGil-Tae Gang-
dc.contributor.affiliatedAuthorYong Hoon Kim-
dc.contributor.affiliatedAuthorJung Hwan Hwang-
dc.contributor.affiliatedAuthorChul Ho Lee-
dc.contributor.alternativeName노정란-
dc.contributor.alternativeName이인경-
dc.contributor.alternativeName이선영-
dc.contributor.alternativeName양금진-
dc.contributor.alternativeName강길태-
dc.contributor.alternativeName김용훈-
dc.contributor.alternativeName황정환-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName이철호-
dc.identifier.bibliographicCitationJournal of Medicinal Food, vol. 14, no. 3, pp. 209-218-
dc.identifier.doi10.1089/jmf.2010.1152-
dc.subject.keywordanti-obesity-
dc.subject.keywordhepatic lipid-
dc.subject.keywordPhellinus baumii-
dc.subject.keywordtriglyceride absorption-
dc.subject.localAnti-obesity-
dc.subject.localanti-obesity-
dc.subject.localantiobesity-
dc.subject.localHepatic lipid-
dc.subject.localhepatic lipid-
dc.subject.localPhellinus baumii-
dc.subject.localtriglyceride absorption-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.