TOX regulates the differentiation of human natural killer cells from hematopoietic stem cells in vitro

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Title
TOX regulates the differentiation of human natural killer cells from hematopoietic stem cells in vitro
Author(s)
So Hyun yoon; S H Lee; Suk Ran Yoon; M S Kim; Z H Piao; P K Myung; Tae-Don KimHai Young Jung; In Pyo Choi
Bibliographic Citation
Immunology Letters, vol. 136, no. 1, pp. 29-36
Publication Year
2011
Abstract
Natural killer (NK) cells act important roles in innate immunity and adaptive immunity. However, the mechanisms governing NK cell development have not been clearly elucidated. Previous studies have shown that an HMG (high-mobility group) protein, TOX, is important for regulating the differentiation program of developing T cells in mice. In this study, we examined the role of TOX in differentiation of human NK cells. Knockdown of TOX in differentiating cells decreased the NK cell population identified by expression of NK surface markers and receptors. In addition, over-expression of TOX enhanced the differentiation of NK cells which give rise to a population showing effector functions of mature NK cells. Moreover, TOX influenced expression of T-bet (T-box expressed in T cells, also as known as Tbx21) during NK cell development. Overall, these results suggest that TOX is required for IL-15-mediated NK cell differentiation and affected expression of T-bet that plays critical roles in NK differentiation and maturation.
Keyword
DifferentiationHigh-mobility group protein TOXNatural killer cellT-bet
ISSN
0165-2478
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.imlet.2010.11.008
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
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