Eudesmanolides from Taraxacum mongolicum and their inhibitory effects on the production of nitric oxide

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Title
Eudesmanolides from Taraxacum mongolicum and their inhibitory effects on the production of nitric oxide
Author(s)
Y H Kim; S J Choo; In Ja RyooJong Seog Ahn; Ick-Dong Yoo
Bibliographic Citation
Archives of Pharmacal Research, vol. 34, no. 1, pp. 37-41
Publication Year
2011
Abstract
A new eudesmanolide, 1β,3β-dihydroxy-eudesman-11(13)-en-6α, 12-olide (1) was isolated and identified from Taraxacum mongolicum, together with two known compounds, 1β,3β-dihydroxyeudesman-6α,12-olide (2) and loliolide (3). The structure of 1 was established by analysis of its physical and spectroscopic data. 1 was found to have an inhibitory activity on nitric oxide production with an IC50 of 38.9 μM in activated RAW 264.7 cells.
Keyword
EudesmanolideNitric oxideTaraxacum mongolicumMacrophage
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-011-0104-5
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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