Redox regulation of the tumor suppressor PTEN by glutaredoxin 5 and Ycp4

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dc.contributor.authorY Kim-
dc.contributor.authorK O Chay-
dc.contributor.authorI Kim-
dc.contributor.authorY B Song-
dc.contributor.authorT Y Kim-
dc.contributor.authorS J Han-
dc.contributor.authorY Ahn-
dc.contributor.authorS H Cho-
dc.contributor.authorKwang Lae Hoe-
dc.contributor.authorB W Ahn-
dc.contributor.authorW K Huh-
dc.contributor.authorS R Lee-
dc.date.accessioned2017-04-19T09:22:26Z-
dc.date.available2017-04-19T09:22:26Z-
dc.date.issued2011-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2011.02.133ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10093-
dc.description.abstractHuman PTEN (phosphatase and tensin homolog deleted on chromosome 10; a phosphatidylinositol 3-phosphatase) expressed in Saccharomyces cerevisiae was oxidized in a time- and H2O2-concentration-dependent manner. Oxidized hPTEN was reduced by cellular reductants as in human cells. The reduction rate of oxidized hPTEN was monitored in S. cerevisiae mutants in which the genes involved in redox homeostasis had been disrupted. Reduction of hPTEN was delayed in each of S. cerevisiae grx5Δ and ycp4Δ mutants. Expression of Grx5 and Ycp4 in each of the mutants rescued the reduction rate of oxidized hPTEN. Furthermore, an in vitro assay revealed that the human Grx5/GSH system efficiently catalyzed the reduction of oxidized hPTEN. These results suggest that the reduction of oxidized hPTEN is regulated by Grx5 and Ycp4-
dc.publisherElsevier-
dc.titleRedox regulation of the tumor suppressor PTEN by glutaredoxin 5 and Ycp4-
dc.title.alternativeRedox regulation of the tumor suppressor PTEN by glutaredoxin 5 and Ycp4-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number1-
dc.citation.endPage180-
dc.citation.startPage175-
dc.citation.volume407-
dc.contributor.affiliatedAuthorKwang Lae Hoe-
dc.contributor.alternativeName김유정-
dc.contributor.alternativeName채기오-
dc.contributor.alternativeName김인영-
dc.contributor.alternativeName송용범-
dc.contributor.alternativeName김태열-
dc.contributor.alternativeName한성정-
dc.contributor.alternativeName안영희-
dc.contributor.alternativeName조승현-
dc.contributor.alternativeName허광래-
dc.contributor.alternativeName안봉환-
dc.contributor.alternativeName허원기-
dc.contributor.alternativeName이승록-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 407, no. 1, pp. 175-180-
dc.identifier.doi10.1016/j.bbrc.2011.02.133-
dc.subject.keywordGlutaredoxin 5-
dc.subject.keywordGlutathione-
dc.subject.keywordHydrogen peroxide-
dc.subject.keywordPTEN-
dc.subject.keywordYcp4-
dc.subject.localGlutaredoxin 5-
dc.subject.localglutathione-
dc.subject.localGlutathione-
dc.subject.localHydrogen peroxide-
dc.subject.localhydrogen peroxide-
dc.subject.localPTEN-
dc.subject.localYcp4-
dc.description.journalClassY-
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