Protein expression analysis in hematopoietic stem cells during osteopontin-induced differentiation of natural killer cells

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dc.contributor.authorM S Kim-
dc.contributor.authorK S Bae-
dc.contributor.authorH J Kim-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorDoo-Byoung Oh-
dc.contributor.authorK W Hwang-
dc.contributor.authorW J Jun-
dc.contributor.authorS I Shim-
dc.contributor.authorK D Kim-
dc.contributor.authorY W Jung-
dc.contributor.authorS Y Park-
dc.contributor.authorKi Sun Kwon-
dc.contributor.authorIn Pyo Choi-
dc.contributor.authorJ W Chung-
dc.date.accessioned2017-04-19T09:22:48Z-
dc.date.available2017-04-19T09:22:48Z-
dc.date.issued2011-
dc.identifier.issn1976-9148-
dc.identifier.uri10.4062/biomolther.2011.19.2.206ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10111-
dc.description.abstractNatural Killer (NK) cells are the lymphocytes that are derived from hematopoietic stem cells, developed in the bone marrow from hematopoietic stem cells (HSC) by sequential acquisition of functional surface receptors, and express the repertoire of inhibitory and activating receptors. Recently, Osteopontin (OPN) has been identifi ed as a critical factor for differentiation of natural killer cells. However, the detailed mechanism of OPN-induced NK differentiation has been still to be elucidated. Here, we determined the signaling pathway and possible receptor for OPN in NK differentiation. OPN induced expression of Bcl-2 and activation of Erk kinase. Inhibition of Erk pathway decreased the effect of OPN on NK differentiation. In addition, the expression of integrin α9 was signifi cantly increased by OPN during NK differentiation, suggesting the possible role of a major signaling molecule for OPN- induced NK differentiation.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleProtein expression analysis in hematopoietic stem cells during osteopontin-induced differentiation of natural killer cells-
dc.title.alternativeProtein expression analysis in hematopoietic stem cells during osteopontin-induced differentiation of natural killer cells-
dc.typeArticle-
dc.citation.titleBiomolecules & Therapeutics-
dc.citation.number2-
dc.citation.endPage210-
dc.citation.startPage206-
dc.citation.volume19-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorDoo-Byoung Oh-
dc.contributor.affiliatedAuthorKi Sun Kwon-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName김미선-
dc.contributor.alternativeName배길수-
dc.contributor.alternativeName김혜진-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName오두병-
dc.contributor.alternativeName황광우-
dc.contributor.alternativeName전우진-
dc.contributor.alternativeName심상인-
dc.contributor.alternativeName김광동-
dc.contributor.alternativeName정용우-
dc.contributor.alternativeName박소영-
dc.contributor.alternativeName권기선-
dc.contributor.alternativeName최인표-
dc.contributor.alternativeName정진웅-
dc.identifier.bibliographicCitationBiomolecules & Therapeutics, vol. 19, no. 2, pp. 206-210-
dc.identifier.doi10.4062/biomolther.2011.19.2.206-
dc.subject.keywordBcl-2-
dc.subject.keywordErk-
dc.subject.keywordHematopoietic stem cells-
dc.subject.keywordNatural killer cells-
dc.subject.keywordOsteopontin-
dc.subject.localBcl-2-
dc.subject.localbcl-2-
dc.subject.localBCL2-
dc.subject.localERK-
dc.subject.localErk-
dc.subject.localHematopoietic stem cell-
dc.subject.localhematopoietic stem cell-
dc.subject.localHematopoietic stem cells-
dc.subject.localNatural killer cell-
dc.subject.localNatural killer cells-
dc.subject.localnatural killer (NK) cells-
dc.subject.localnatural killer cell-
dc.subject.localOsteopontin-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
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