Development of a surface plasmon resonance-based immunosensor for the rapid detection of cardiac troponin I

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dc.contributor.authorY C Kwon-
dc.contributor.authorMin-Gon Kim-
dc.contributor.authorE M Kim-
dc.contributor.authorYong Beom Shin-
dc.contributor.authorS K Lee-
dc.contributor.authorS D Lee-
dc.contributor.authorM J Cho-
dc.contributor.authorH S Ro-
dc.date.accessioned2017-04-19T09:22:57Z-
dc.date.available2017-04-19T09:22:57Z-
dc.date.issued2011-
dc.identifier.issn0141-5492-
dc.identifier.uri10.1007/s10529-010-0509-0ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10125-
dc.description.abstractThe concentration of cardiac troponin I (cTnI) in blood is an important marker for heart muscle cell damage. A surface plasmon resonance (SPR)-based immunosensor was devised for the rapid and specific detection of cTnI. It was constructed by crosslinking a monoclonal antibody P-II-13, which was generated against a loop region (aa 84-94) of cTnI protein as an epitope peptide, onto a chemically modified thin gold film. The performance of the sensor was examined with respect to the SPR signal intensity versus cTnI concentration. The signal intensity was directly correlated with the cTnI concentration in the range of 0-160 μg/l. The sensor signal was saturated when the concentration of cTnI approached 660 μg/l with the SPR intensity of 172 RU. The lower detection limit of the sensor was 68 ng/l cTnI, which was comparable to ELISA-based commercial cTnI detection systems.-
dc.publisherSpringer-
dc.titleDevelopment of a surface plasmon resonance-based immunosensor for the rapid detection of cardiac troponin I-
dc.title.alternativeDevelopment of a surface plasmon resonance-based immunosensor for the rapid detection of cardiac troponin I-
dc.typeArticle-
dc.citation.titleBiotechnology Letters-
dc.citation.number5-
dc.citation.endPage927-
dc.citation.startPage921-
dc.citation.volume33-
dc.contributor.affiliatedAuthorMin-Gon Kim-
dc.contributor.affiliatedAuthorYong Beom Shin-
dc.contributor.alternativeName권영철-
dc.contributor.alternativeName김민곤-
dc.contributor.alternativeName김은미-
dc.contributor.alternativeName신용범-
dc.contributor.alternativeName이석기-
dc.contributor.alternativeName이성동-
dc.contributor.alternativeName조명제-
dc.contributor.alternativeName노현수-
dc.identifier.bibliographicCitationBiotechnology Letters, vol. 33, no. 5, pp. 921-927-
dc.identifier.doi10.1007/s10529-010-0509-0-
dc.subject.keywordBiosensor-
dc.subject.keywordMonoclonal antibody-
dc.subject.keywordMyocardial-
dc.subject.keywordSurface plasmon resonance-based-
dc.subject.keywordTroponin-
dc.subject.localbiosensor-
dc.subject.localBio-sensor-
dc.subject.localBiosensor-
dc.subject.localbiosensors-
dc.subject.localBiosensors-
dc.subject.localMonoclonal antibody (mAb)-
dc.subject.localMonoclonal antibodies-
dc.subject.localMonoclonal Antibodies-
dc.subject.localMonoclonal antibody-
dc.subject.localmonoclonal antibody-
dc.subject.localMonoclonal Antibody-
dc.subject.localmonoclonal antibodies-
dc.subject.localMyocardial-
dc.subject.localSurface plasmon resonance-based-
dc.subject.localTroponin-
dc.description.journalClassY-
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Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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