Peroxiredoxin II preserves cognitive function against age-linked hippocampal oxidative damage

Cited 46 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorM H Jin-
dc.contributor.authorY S Kim-
dc.contributor.authorS H Lee-
dc.contributor.authorYeesook Cho-
dc.contributor.authorK J Cho-
dc.contributor.authorKyu-Sun Lee-
dc.contributor.authorY I Kim-
dc.contributor.authorG W Kim-
dc.contributor.authorJ M Kim-
dc.contributor.authorT H Lee-
dc.contributor.authorY H Lee-
dc.contributor.authorM Shong-
dc.contributor.authorH C Kim-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorD S Lee-
dc.date.accessioned2017-04-19T09:22:57Z-
dc.date.available2017-04-19T09:22:57Z-
dc.date.issued2011-
dc.identifier.issn0197-4580-
dc.identifier.uri10.1016/j.neurobiolaging.2009.05.017ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10127-
dc.description.abstractReactive oxygen species (ROS), routinely produced in biological reactions, contribute to both normal aging and age-related decline in cognitive function. However, little is known regarding the involvement of specific antioxidants in the underlying mechanism(s). Here, we examined if peroxiredoxin II (Prx II) scavenges intracellular ROS that cause age-dependent mitochondrial decay in hippocampal CA1 pyramidal neurons and subsequent impairment of learning and memory. Age-dependent mitochondrial ROS generation and long-term potentiation (LTP) decline were more prominent in hippocampal neurons in Prx II-/- than in wild-type mice. Additionally, Prx II-/- mice failed to activate synaptic plasticity-related cellular signaling pathways involving CREB, CaMKII, and ERK, or to maintain functional integrity of their mitochondria. Dietary vitamin E alleviated Prx II deficiency-related deficits, including mitochondrial decay and CREB signaling, resulting in restoration of the abrupt cognitive decline in aged Prx II-/- mice. These results suggest that Prx II help maintain hippocampal synaptic plasticity against age-related oxidative damage.-
dc.publisherElsevier-
dc.titlePeroxiredoxin II preserves cognitive function against age-linked hippocampal oxidative damage-
dc.title.alternativePeroxiredoxin II preserves cognitive function against age-linked hippocampal oxidative damage-
dc.typeArticle-
dc.citation.titleNeurobiology of Aging-
dc.citation.number6-
dc.citation.endPage1068-
dc.citation.startPage1054-
dc.citation.volume32-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorYeesook Cho-
dc.contributor.affiliatedAuthorKyu-Sun Lee-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.affiliatedAuthorDae Yeul Yu-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName김윤식-
dc.contributor.alternativeName이상희-
dc.contributor.alternativeName조이숙-
dc.contributor.alternativeName조경주-
dc.contributor.alternativeName이규선-
dc.contributor.alternativeName김양인-
dc.contributor.alternativeName김경환-
dc.contributor.alternativeName김진만-
dc.contributor.alternativeName이태훈-
dc.contributor.alternativeName이영호-
dc.contributor.alternativeName송민호-
dc.contributor.alternativeName김형천-
dc.contributor.alternativeName장규태-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName이동석-
dc.identifier.bibliographicCitationNeurobiology of Aging, vol. 32, no. 6, pp. 1054-1068-
dc.identifier.doi10.1016/j.neurobiolaging.2009.05.017-
dc.subject.keywordAging-
dc.subject.keywordHippocampus-
dc.subject.keywordLong-term potentiation-
dc.subject.keywordMitochondria-
dc.subject.keywordPeroxiredoxin-
dc.subject.keywordReactive oxygen species-
dc.subject.localAging-
dc.subject.localaging-
dc.subject.localhippocampus-
dc.subject.localHippocampus-
dc.subject.localLong-term potentiation-
dc.subject.localMitochondria-
dc.subject.localmitochondria-
dc.subject.localPeroxiredoxin-
dc.subject.localperoxiredoxin-
dc.subject.localPeroxiredoxins-
dc.subject.localReactive oxidative species-
dc.subject.localReactive oxygen species(ROS)-
dc.subject.localReactive oxygen species-
dc.subject.localReactive Oxygen Species (ROS)-
dc.subject.localReactive Oxygen Species-
dc.subject.localROS-
dc.subject.localReactive oxygen species (ROS)-
dc.subject.localreactive oxygen species-
dc.subject.localreactive oxygen species (ROS)-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.