Characterization of ERp29 and ADP-ribosylation factor 5 interaction = ERp29와 ADP-ribosylation factor 5의 결합 특성

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Title
Characterization of ERp29 and ADP-ribosylation factor 5 interaction = ERp29와 ADP-ribosylation factor 5의 결합 특성
Author(s)
K Kwon; D H Seog; S W Kim; Kweon Yu; O Y Kwon
Bibliographic Citation
Korean Journal of Life Sciences, vol. 21, no. 4, pp. 613-615
Publication Year
2011
Abstract
ERp29 is a endoplasmic reticulum (ER) lumenal resident protein that shows sequence similarity to the protein disulfide isomerase family. Its biological function is thought to play a role in the processing of secretory proteins within the ER, possibly by participating in the folding of proteins in the ER. Although some data on ERp29 have been reported, its normal functions are still unclear. To gain insights into the function of ERp29, we identified ARF5 protein as a protein that interacts with ERp29 using yeast two-hybrid screening and GST pull-down assay. Interaction between ERp29 and ARF5 was detected under normal cell conditions but not under ER stress conditions. This result may provide a clue for understanding ERp29 biological functions.
Keyword
Endoplasmic reticulum protein 29 (ERp29)binding proteinADP-ribosylation factor 5(ARF5)
ISSN
I000-0052
Publisher
South Korea
DOI
http://dx.doi.org/10.5352/JLS.2011.21.4.613
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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