A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | S Y Han | - |
| dc.contributor.author | Young Won Chin | - |
| dc.date.accessioned | 2017-04-19T09:23:28Z | - |
| dc.date.available | 2017-04-19T09:23:28Z | - |
| dc.date.issued | 2011 | - |
| dc.identifier.issn | 1475-6366 | - |
| dc.identifier.uri | 10.3109/14756366.2010.515215 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10145 | - |
| dc.description.abstract | Bioactivity-guided investigation for the rhizomes of Anemarrhena asphodeloides using the Fms-like tyrosine kinase 3 (FLT3) inhibition assay led to the identification of an active xanthone, mangiferin. Mangiferin was found to inhibit activity of the FLT3 wild type and a mutated form of FLT3 with IC 50 values of 0.7 and 1.2μM, respectively. Furthermore, this compound was assessed with a small panel of select kinases anaplastic lymphoma kinase (ALK), insulin receptor, and epidermal growth factor receptor) and was also found to be active in ALK assay. | - |
| dc.publisher | T&F (Taylor & Francis) | - |
| dc.title | A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides | - |
| dc.title.alternative | A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides | - |
| dc.type | Article | - |
| dc.citation.title | Journal of Enzyme Inhibition and Medicinal Chemistry | - |
| dc.citation.number | 3 | - |
| dc.citation.endPage | 448 | - |
| dc.citation.startPage | 445 | - |
| dc.citation.volume | 26 | - |
| dc.contributor.affiliatedAuthor | Young Won Chin | - |
| dc.contributor.alternativeName | 한선영 | - |
| dc.contributor.alternativeName | 진영원 | - |
| dc.identifier.bibliographicCitation | Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 26, no. 3, pp. 445-448 | - |
| dc.identifier.doi | 10.3109/14756366.2010.515215 | - |
| dc.subject.keyword | ALK | - |
| dc.subject.keyword | Anemarrhena asphodeloides | - |
| dc.subject.keyword | FLT3 | - |
| dc.subject.keyword | mangiferin | - |
| dc.subject.keyword | xanthone | - |
| dc.subject.local | ALK | - |
| dc.subject.local | Anemarrhena asphodeloides | - |
| dc.subject.local | Anemarrhena asphodeloide | - |
| dc.subject.local | FLT3 | - |
| dc.subject.local | mangiferin | - |
| dc.subject.local | Mangiferin | - |
| dc.subject.local | Xanthone | - |
| dc.subject.local | xanthones | - |
| dc.subject.local | xanthone | - |
| dc.description.journalClass | Y | - |
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