PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase

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dc.contributor.authorY Lee-
dc.contributor.authorSu Jin Kim-
dc.contributor.authorHye-Jin Min-
dc.contributor.authorJi Yoon Jo-
dc.contributor.authorE H Park-
dc.contributor.authorSang Seok Koh-
dc.date.accessioned2017-04-19T09:23:30Z-
dc.date.available2017-04-19T09:23:30Z-
dc.date.issued2011-
dc.identifier.issnI000-0028-
dc.identifier.uri10.3858/emm.2011.43.5.030ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10150-
dc.description.abstractPancreatic cancer is a notorious disease with a poor prognosis and low survival rates, which is due to limited advances in understanding of the molecular mechanism and inadequate development of effective treatment options over the decades. In previous studies, we demonstrated that a novel soluble protein named pancreatic adenocarcinoma up-regulated factor (PAUF) acts on tumor and immune cells and plays an important role in metastasis and progression of pancreatic cancer. Here we show that PAUF promotes adhesiveness of pancreatic cancer cells to various extracellular matrix (ECM). Our results further support a positive correlation of activation and expression of focal adhesion kinase (FAK), a key player in tumor cell metastasis and survival, with PAUF expression. PAUF-mediated adhesiveness was significantly attenuated upon blockade of the FAK pathway. Moreover, PAUF appeared to enhance resistance of pancreatic cancer cells to anoikis via modulation of FAK. Our results suggest that PAUF-mediated FAK activation plays an important role in pancreatic cancer progression.-
dc.publisherSpringer-Nature Pub Group-
dc.titlePAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase-
dc.title.alternativePAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase-
dc.typeArticle-
dc.citation.titleExperimental and Molecular Medicine-
dc.citation.number5-
dc.citation.endPage297-
dc.citation.startPage291-
dc.citation.volume43-
dc.contributor.affiliatedAuthorSu Jin Kim-
dc.contributor.affiliatedAuthorHye-Jin Min-
dc.contributor.affiliatedAuthorJi Yoon Jo-
dc.contributor.affiliatedAuthorSang Seok Koh-
dc.contributor.alternativeName이양순-
dc.contributor.alternativeName김수진-
dc.contributor.alternativeName민혜진-
dc.contributor.alternativeName조지윤-
dc.contributor.alternativeName박은혜-
dc.contributor.alternativeName고상석-
dc.identifier.bibliographicCitationExperimental and Molecular Medicine, vol. 43, no. 5, pp. 291-297-
dc.identifier.doi10.3858/emm.2011.43.5.030-
dc.subject.keywordAdhesion-
dc.subject.keywordAnoikis-
dc.subject.keywordFAK-
dc.subject.keywordPancreatic cancer-
dc.subject.keywordPAUF-
dc.subject.keywordSignaling-
dc.subject.localadhesion-
dc.subject.localAdhesion-
dc.subject.localAnoikis-
dc.subject.localFAK-
dc.subject.localpancreatic cancer-
dc.subject.localPancreatic cancer-
dc.subject.localPAUF-
dc.subject.localSignaling-
dc.subject.localsignaling-
dc.subject.localSIGNALNIG-
dc.subject.localSIGNALING-
dc.description.journalClassY-
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