Anti-inflammatory activity of constituents from Glechoma hederacea var. longituba

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Title
Anti-inflammatory activity of constituents from Glechoma hederacea var. longituba
Author(s)
J Kim; S Song; I Lee; Y Kim; Ick-Dong Yoo; In Ja Ryoo; K Bae
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 11, pp. 3483-3487
Publication Year
2011
Abstract
Rosmarinic acid, its analogues, and a phenolic compound were obtained from G. hederacea var. longituba. There were two new compounds, methyl isoferuloyl-7-(3,4-dihydroxyphenyl) lactate (1) and benzyl-4′-hydroxy- benzoyl-3′-O-β-d-glucopyranoside (4), and four known compounds (2, 3, 5 and 6). The structures of these compounds were determined on the basis of spectroscopic methods. Each compound was tested by NF-κB luciferase assay and three rosmarinic acid analogues inhibited NF-κB production and the induction of COX-2 and iNOS mRNA in HepG2 cells.
Keyword
Glechoma hederaceaCOX-2InflammationiNOSNf-κBRosmarinic acid
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2011.02.002
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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