Anticomplement activity of compounds isolated from the roots of euphorbia kansui

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Title
Anticomplement activity of compounds isolated from the roots of euphorbia kansui
Author(s)
G Li; J H Kim; G Shen; Joongku Lee; Hyeong Kyu Lee; Sei Ryang Oh
Bibliographic Citation
Journal of Korean Society for Applied Biological Chemistry, vol. 54, no. 2, pp. 159-162
Publication Year
2011
Abstract
The anticomplement activity-guided fractionation of the methanol extract of Euphorbia kansui L. resulted in isolation of three diterpenes, two triterpenes, and two sterols (1-7) from ethyl acetate fraction. By spectroscopic analysis, their chemical structures were elucidated as: β-amyrin (1); kansuiphorin C (2); 3-O-(2'E,4'Z-decadienoyl)-ingenol (3); 3-O-(2,3-dimethylbutyryl)-13-O-ndodecanoyl- 13-hydroxyingenol (4); β-sitosterol (5); α-euphol (6); β-sitosterol-3-O-β-Dglucopyranoside (7). These compounds were investigated in vitro for their anticomplement activity against the classical pathway of the complement system, with compounds 2-4 exhibiting significant anticomplement activity with respective 50% inhibitory concentration values of 44.1±3.8, 89.5±5.5, and 152.1±6.2 μM.
Keyword
anticomplement activityEuphorbia kansuikansuiphorin CO-(2′E,4′Z-decadienoyl)-ingenol3-O-(2,3-dimethylbutyryl)-13-O-n-dodecanoyl-13-hydroxyingenol
ISSN
I000-0171
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.3839/jksabc.2011.026
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
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