(-)-pinoresinol monomethyl ether inhibits LPS-induced iNOS and Cox-2 expression via the attenuation of NF-κb in Raw 264.7 macrophage cells

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dc.contributor.authorB Y Park-
dc.contributor.authorM Y Lee-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorY W Chin-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorSei Ryang Oh-
dc.date.accessioned2017-04-19T09:23:31Z-
dc.date.available2017-04-19T09:23:31Z-
dc.date.issued2011-
dc.identifier.issnI000-0171-
dc.identifier.uri10.3839/jksabc.2011.027ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10155-
dc.description.abstractAnti-inflammatory effects of (-)-pinoresinol monomethyl ether (PME) were evaluated on lipopolysaccharide (LPS)-treated Raw 264.7 macrophage cells. PME inhibited translocation of p65-nuclear factor-κB (NF-κB) into the nucleus in immunocytochemical analysis for NF-κB activation, expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in Western blotting, as well as production of pro-inflammatory mediators, such as nitric oxide (NO), tumor necrosis factor (TNF-α), and prostaglandin E2 (PGE2) in LPS-induced Raw 264.7 cells. These results suggest the anti-inflammatory activity of PME could be due to the down-regulation of iNOS, COX-2, TNF-α, and PGE2 in activated Raw 264.7 cells through NF-κB-dependent pathways.-
dc.publisherKorea Soc-Assoc-Inst-
dc.title(-)-pinoresinol monomethyl ether inhibits LPS-induced iNOS and Cox-2 expression via the attenuation of NF-κb in Raw 264.7 macrophage cells-
dc.title.alternative(-)-pinoresinol monomethyl ether inhibits LPS-induced iNOS and Cox-2 expression via the attenuation of NF-κb in Raw 264.7 macrophage cells-
dc.typeArticle-
dc.citation.titleJournal of Korean Society for Applied Biological Chemistry-
dc.citation.number2-
dc.citation.endPage168-
dc.citation.startPage163-
dc.citation.volume54-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.alternativeName박보영-
dc.contributor.alternativeName이미영-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName진영원-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName오세량-
dc.identifier.bibliographicCitationJournal of Korean Society for Applied Biological Chemistry, vol. 54, no. 2, pp. 163-168-
dc.identifier.doi10.3839/jksabc.2011.027-
dc.subject.keyword(-)-pinoresinol monomethyl ether-
dc.subject.keywordCox-2-
dc.subject.keywordInducible nitric oxide synthase-
dc.subject.keywordNitric oxide-
dc.subject.keywordNuclear factor-κb-
dc.subject.keywordProstaglandin e2-
dc.subject.keywordTumor necrosis factor-
dc.subject.local(-)-pinoresinol monomethyl ether-
dc.subject.localCOX-2-
dc.subject.localCox-2-
dc.subject.localInducible nitric oxide synthase (iNOS)-
dc.subject.localInducible nitric oxide synthase-
dc.subject.localinducible nnitric oxide synthase-
dc.subject.localiNOS-
dc.subject.localInducible nitric oxide synthease (iNOS)-
dc.subject.localINOS-
dc.subject.localinducible nitric oxide synthase-
dc.subject.localNO-
dc.subject.localnitric oxide-
dc.subject.localnitric oxide (NO)-
dc.subject.localNitric oxide-
dc.subject.localNO (Nitric oxide)-
dc.subject.localnitric oxide.-
dc.subject.localNitric oxid-
dc.subject.localNitric oxide (NO)-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localprostaglandin E2-
dc.subject.localProstaglandin E2-
dc.subject.localProstaglandin e2-
dc.subject.localtumor necrosis factor-
dc.subject.localTumor necrosis factor-
dc.subject.localtumor necrosis factor--
dc.description.journalClassN-
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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