Direct reprogramming of mouse fibroblasts to neural progenitors

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dc.contributor.authorJanghwan Kim-
dc.contributor.authorJ A Efe-
dc.contributor.authorS Zhu-
dc.contributor.authorM Talantova-
dc.contributor.authorX Yuan-
dc.contributor.authorS Wang-
dc.contributor.authorS A Lipton-
dc.contributor.authorK Zhang-
dc.contributor.authorS Ding-
dc.date.accessioned2017-04-19T09:23:33Z-
dc.date.available2017-04-19T09:23:33Z-
dc.date.issued2011-
dc.identifier.issn0027-8424-
dc.identifier.uri10.1073/pnas.1103113108ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10165-
dc.description.abstractThe simple yet powerful technique of induced pluripotency may eventually supply a wide range of differentiated cells for cell therapy and drug development. However, making the appropriate cells via induced pluripotent stem cells (iPSCs) requires reprogramming of somatic cells and subsequent redifferentiation. Given how arduous and lengthy this process can be, we sought to determine whether it might be possible to convert somatic cells into lineage-specific stem/progenitor cells of another germ layer in one step, bypassing the intermediate pluripotent stage. Here we show that transient induction of the four reprogramming factors (Oct4, Sox2, Klf4, and c-Myc) can efficiently transdifferentiate fibroblasts into functional neural stem/progenitor cells (NPCs) with appropriate signaling inputs. Compared with induced neurons (or iN cells, which are directly converted from fibroblasts), transdifferentiated NPCs have the distinct advantage of being expandable in vitro and retaining the ability to give rise to multiple neuronal subtypes and glial cells. Our results provide a unique paradigm for iPSC-factor - based reprogramming by demonstrating that it can be readily modified to serve as a general platform for transdifferentiation.-
dc.publisherNatl Acad Sciences-
dc.titleDirect reprogramming of mouse fibroblasts to neural progenitors-
dc.title.alternativeDirect reprogramming of mouse fibroblasts to neural progenitors-
dc.typeArticle-
dc.citation.titleProceedings of National Academy of Sciences of United States of America-
dc.citation.number19-
dc.citation.endPage7843-
dc.citation.startPage7838-
dc.citation.volume108-
dc.contributor.affiliatedAuthorJanghwan Kim-
dc.contributor.alternativeName김장환-
dc.contributor.alternativeNameEfe-
dc.contributor.alternativeNameZhu-
dc.contributor.alternativeNameTalantova-
dc.contributor.alternativeNameYuan-
dc.contributor.alternativeNameWang-
dc.contributor.alternativeNameLipton-
dc.contributor.alternativeNameZhang-
dc.contributor.alternativeNameDing-
dc.identifier.bibliographicCitationProceedings of National Academy of Sciences of United States of America, vol. 108, no. 19, pp. 7838-7843-
dc.identifier.doi10.1073/pnas.1103113108-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
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