The conformation and CETP inhibitory activity of [10]-dehydrogingerdione isolated from Zingiber officinale = 생강으로부터 분리한 [10]-데하이드로 진저다이온의 배좌와 CETP 저해활성

Cited 21 time in scopus
Metadata Downloads
Title
The conformation and CETP inhibitory activity of [10]-dehydrogingerdione isolated from Zingiber officinale = 생강으로부터 분리한 [10]-데하이드로 진저다이온의 배좌와 CETP 저해활성
Author(s)
S Y Choi; G S Park; Sung Yoon Lee; Ji Yeon Kim; Young Kook Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 34, no. 5, pp. 727-731
Publication Year
2011
Abstract
In the course of searching for cholesteryl ester transfer protein (CETP) inhibitors from natural sources, a new type of CETP inhibitor, [10]-dehydrogingerdione (1), was isolated from the extract of rhizomes of Zingiber officinale Roscoe. By NMR spectroscopic analysis of its (1)HNMR, (13)C-NMR, and (1)H-(1)H COSY, HMBC, HMQC and NOESY, more precise structure, compared with its originally proposed structures, of [10]-dehydrogingerdione has been elucidated. This active compound inhibited human plasma CETP with IC(50) values of 35 μM.
Keyword
Cholesteryl ester transfer proteinGingiber officinaleInhibitor
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-011-0505-5
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.