The conformation and CETP inhibitory activity of [10]-dehydrogingerdione isolated from Zingiber officinale = 생강으로부터 분리한 [10]-데하이드로 진저다이온의 배좌와 CETP 저해활성
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- Title
- The conformation and CETP inhibitory activity of [10]-dehydrogingerdione isolated from Zingiber officinale = 생강으로부터 분리한 [10]-데하이드로 진저다이온의 배좌와 CETP 저해활성
- Author(s)
- S Y Choi; G S Park; Sung Yoon Lee; Ji Yeon Kim; Young Kook Kim
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 34, no. 5, pp. 727-731
- Publication Year
- 2011
- Abstract
- In the course of searching for cholesteryl ester transfer protein (CETP) inhibitors from natural sources, a new type of CETP inhibitor, [10]-dehydrogingerdione (1), was isolated from the extract of rhizomes of Zingiber officinale Roscoe. By NMR spectroscopic analysis of its (1)HNMR, (13)C-NMR, and (1)H-(1)H COSY, HMBC, HMQC and NOESY, more precise structure, compared with its originally proposed structures, of [10]-dehydrogingerdione has been elucidated. This active compound inhibited human plasma CETP with IC(50) values of 35 μM.
- Keyword
- Cholesteryl ester transfer proteinGingiber officinaleInhibitor
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- DOI
- http://dx.doi.org/10.1007/s12272-011-0505-5
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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