Open Access@KRIBBDivision of A.I. & Biomedical ResearchGenomic Medicine Research Center1. Journal Articles
Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part I
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | J S Yang | - |
| dc.contributor.author | D Song | - |
| dc.contributor.author | B Lee | - |
| dc.contributor.author | W J Ko | - |
| dc.contributor.author | S K Park | - |
| dc.contributor.author | Mi Sun Won | - |
| dc.contributor.author | K Lee | - |
| dc.contributor.author | H M Kim | - |
| dc.contributor.author | G Han | - |
| dc.date.accessioned | 2017-04-19T09:23:52Z | - |
| dc.date.available | 2017-04-19T09:23:52Z | - |
| dc.date.issued | 2011 | - |
| dc.identifier.issn | 0223-5234 | - |
| dc.identifier.uri | 10.1016/j.ejmech.2011.04.009 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10178 | - |
| dc.description.abstract | We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents. | - |
| dc.publisher | Elsevier | - |
| dc.title | Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part I | - |
| dc.title.alternative | Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part I | - |
| dc.type | Article | - |
| dc.citation.title | European Journal of Medicinal Chemistry | - |
| dc.citation.number | 7 | - |
| dc.citation.endPage | 2866 | - |
| dc.citation.startPage | 2861 | - |
| dc.citation.volume | 46 | - |
| dc.contributor.affiliatedAuthor | Mi Sun Won | - |
| dc.contributor.alternativeName | 양지선 | - |
| dc.contributor.alternativeName | 송두나 | - |
| dc.contributor.alternativeName | 이보아 | - |
| dc.contributor.alternativeName | 고원진 | - |
| dc.contributor.alternativeName | 박성규 | - |
| dc.contributor.alternativeName | 원미선 | - |
| dc.contributor.alternativeName | 이기호 | - |
| dc.contributor.alternativeName | 김환묵 | - |
| dc.contributor.alternativeName | 한균희 | - |
| dc.identifier.bibliographicCitation | European Journal of Medicinal Chemistry, vol. 46, no. 7, pp. 2861-2866 | - |
| dc.identifier.doi | 10.1016/j.ejmech.2011.04.009 | - |
| dc.subject.keyword | Aliphatic amido-quaternary ammonium salts | - |
| dc.subject.keyword | GTPase RAt Sarcoma (Ras) | - |
| dc.subject.keyword | NSC126188 | - |
| dc.subject.keyword | Perifosine | - |
| dc.subject.keyword | Piperazine alkyl derivatives | - |
| dc.subject.keyword | RhoB | - |
| dc.subject.local | Aliphatic amido-quaternary ammonium salts | - |
| dc.subject.local | GTPase rat sarcoma (Ras) | - |
| dc.subject.local | GTPase RAt Sarcoma (Ras) | - |
| dc.subject.local | NSC126188 | - |
| dc.subject.local | Perifosine | - |
| dc.subject.local | Piperazine alkyl derivatives | - |
| dc.subject.local | Piperazine alkyl derivative | - |
| dc.subject.local | RhoB | - |
| dc.subject.local | Rhob | - |
| dc.description.journalClass | Y | - |
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