New sesquiterpene lactones from Glechoma hederacea L. and their cytotoxic effects on human cancer cell lines

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Title
New sesquiterpene lactones from Glechoma hederacea L. and their cytotoxic effects on human cancer cell lines
Author(s)
J Kim; I Lee; D Ha; J Seo; B Min; Ick-Dong Yoo; K Bae
Bibliographic Citation
Planta Medica, vol. 77, no. 9, pp. 955-957
Publication Year
2011
Abstract
Three new sesquiterpene lactones, 1α,10β-epoxy-4-hydroxy- glechoma-5-en-olide (1), 1β,10α-epoxy-4,8-dihydroxy-glechoma-5-en- olide (2), and 1β,10α;4α,5β-diepoxy-8-methoxy-glechoman- 8α,12-olide (3), were isolated from the whole plant of Glechoma hederacea, together with four known sesquiterpene lactones. The structures of the three new sesquiterpene lactones were determined by spectroscopic evidence. Cytotoxic effects of the isolated compounds were examined against MDA-MB-231 (breast), HCT116 (colon), SW620 (colon), and DU145 (prostate) human cancer cell lines.
Keyword
cytotoxicityGlechoma hederaceaLabiataesesquiterpene lactone
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-0030-1250665
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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