An autonomous CMOS hysteretic sensor for the detection of desorption-free DNA hybridization

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Title
An autonomous CMOS hysteretic sensor for the detection of desorption-free DNA hybridization
Author(s)
K H Lee; S H Choi; J O Lee; Mi Jin Sohn; J B Yoon; G H Cho
Bibliographic Citation
Biosensors & Bioelectronics, vol. 26, no. 11, pp. 4591-4595
Publication Year
2011
Abstract
This paper describes a sensor for label-free, fully electrical detection of DNA hybridization based on capacitive changes in the electrode-electrolyte interface. The sensor measures capacitive changes in real time according to a charging-discharging principle that is limited by the hysteresis window. In addition, a novel autonomous searching technique, which exclusively monitors desorption-free hybridized electrodes among electrode arrays, enhances the performance of the sensor compared with conventional capacitive measurement. The sensor system achieves a detection range of 80. dB. The integrated circuit sensor is fabricated with a 0.35 μm CMOS process. The proposed sensor offers rapid, robust and inexpensive measurement of capacitance with highly integrated detection circuitry. It also facilitates quantitative evaluations of molecular densities on a chip with distinctive impedance variations by monitoring desorption-free hybridized electrodes. Our electrical biosensor has great potential for use with bio analytical tools and point-of-care diagnosis.
Keyword
CapacitanceDesorptionDNA hybridizationImpedanceSensor
ISSN
0956-5663
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bios.2011.04.033
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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