Features and applications of bacterial sialidases = 세균 시알리다아제의 특성과 응용

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Title
Features and applications of bacterial sialidases = 세균 시알리다아제의 특성과 응용
Author(s)
Seong Hun KimDoo-Byoung Oh; H A Kang; Oh Suk Kwon
Bibliographic Citation
Applied Microbiology and Biotechnology, vol. 91, no. 1, pp. 1-15
Publication Year
2011
Abstract
Sialidases, or neuraminidases (EC 3.2.1.18), belong to a class of glycosyl hydrolases that release terminal N-acylneuraminate residues from the glycans of glycoproteins, glycolipids, and polysaccharides. In bacteria, sialidases can be used to scavenge sialic acids as a nutrient from various sialylated substrates or to recognize sialic acids exposed on the surface of the host cell. Despite the fact that bacterial sialidases share many structural features, their biochemical properties, especially their linkage and substrate specificities, vary widely. Bacterial sialidases can catalyze the hydrolysis of terminal sialic acids linked by the α(2,3)-, α(2,6)-, or α(2,8)-linkage to a diverse range of substrates. In addition, some of these enzymes can catalyze the transfer of sialic acids from sialoglycans to asialoglycoconjugates via a transglycosylation reaction mechanism. Thus, some bacterial sialidases have been applied to synthesize complex sialyloligosaccharides through chemoenzymatic approaches and to analyze the glycan structure. In this review article, the biochemical features of bacterial sialidases and their potential applications in regioselective hydrolysis reactions as well as sialylation by transglycosylation for the synthesis of sialylated complex glycans are discussed.
Keyword
Chemoenzymatic synthesisIn vitro trans-sialylationRegioselectivitySialic acidSialidaseSialoglycoconjugate
ISSN
0175-7598
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s00253-011-3307-2
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Bio Technology Innovation > SME Support Center > 1. Journal Articles
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