Rheumatic arthrits-induced alteration of morphology and function in muscles = 류마티스 관절염에 의한 근육에서의 형태 및 기능 변화

Cited 0 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorY Hong-
dc.contributor.authorJ H Kim-
dc.contributor.authorP K Javaregowda-
dc.contributor.authorS K Lee-
dc.contributor.authorSang Rae Lee-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorY Hong-
dc.description.abstractClinical arthritis is typically divided into rheumatoid arthritis (RA) and osteoarthritis (OA). Arthritis-induced muscle weakness is a major problem in aged people, leading to a disturbance of balance during the gait cycle and frequent falls. The purposes of the present study were to confirm fiber type-dependent expression of muscle atrophy markers induced by arthritis and to identify the relationship between clinical signs and expression of muscle atrophy markers. Mice were divided into four experimental groups as follows: (1) negative control (normal), (2) positive control (CFA+acetic acid), (3) RA group (CFA+acetic acid+type Ⅱ collagen), and (4) aging-induced OA group. DBA/1J mice (8 weeks of age) were injected with collagen (50 μg/kg), and physiological (body weight) and pathological (arthritis score and paw thickness) parameters were measured once per week. The gastrocnemius muscle from animals in each group was removed, and the expression of muscle atrophy markers (MAFbx and MuRF1) and myosin heavy chain isoforms were analyzed by reverse transcription-polymerase chain reaction. No significant change in body weight occurred between control groups and collagen-induced RA mice at week 10. However, bovine type Ⅱ collagen induced a dramatic increase in clinical score or paw thickness at week 10 (p<0.01). Concomitantly, the expression of the muscle atrophy marker MAFbx was upregulated in the RA and OA groups (p<0.01). A dramatic reduction in myosin heavy chain (MHC)-Iβ was seen in the gastrocnemius muscles from RA and OA mice, while only a slight decrease in MHC-Ⅱb was seen. These results suggest that muscle atrophy gene expression occurred in a fiber type-specific manner in both RA- and OA-induced mice. The present study suggests evidence regarding why different therapeutic interventions are required between RA and OA.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleRheumatic arthrits-induced alteration of morphology and function in muscles = 류마티스 관절염에 의한 근육에서의 형태 및 기능 변화-
dc.title.alternativeRheumatic arthrits-induced alteration of morphology and function in muscles-
dc.citation.titleReproductive & Developmental Biology-
dc.contributor.affiliatedAuthorSang Rae Lee-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.identifier.bibliographicCitationReproductive & Developmental Biology, vol. 35, no. 2, pp. 151-157-
dc.subject.keywordRheumatoid arthritis-
dc.subject.keywordMuscle atrophy-
dc.subject.keywordTherapeutic intervention-
dc.subject.localRheumatoid Arthritis-
dc.subject.localRheumatoid arthritis-
dc.subject.localrheumatoid arthritis (RA)-
dc.subject.localrheumatoid arthritis-
dc.subject.localMuscle atrophy-
dc.subject.localmuscle atrophy-
dc.subject.localTherapeutic intervention-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.