Lipid-soluble ginseng extract induces apoptosis and G0/G1 cell cycle arrest in NCI-H460 human lung cancer cells

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dc.contributor.authorM R Kang-
dc.contributor.authorH M Kim-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorK Lee-
dc.contributor.authorS D Lee-
dc.contributor.authorD H Hyun-
dc.contributor.authorM J In-
dc.contributor.authorS K Park-
dc.contributor.authorD C Kim-
dc.date.accessioned2017-04-19T09:24:36Z-
dc.date.available2017-04-19T09:24:36Z-
dc.date.issued2011-
dc.identifier.issn0921-9668-
dc.identifier.uri10.1007/s11130-011-0232-6ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10255-
dc.description.abstractThis study was performed to elucidate the anticancer mechanism of a lipid-soluble ginseng extract (LSGE) by analyzing induction of apoptosis and arrest of cell cycle progression using the NCI-H460 human lung cancer cell line. Proliferation of NCI-H460 cells was potently inhibited by LSGE in a dose-dependent manner. The cell cycle arrest at the G0/G1 phase in NCI-H460 cells was induced by LSGE. The percentage of G0/G1 phase cells significantly increased, while that of S phase cells decreased after treatment with LSGE. The expr.occurred through apoptosis, which was accompanied by increasing the activity of caspases including caspase-8, caspase-9 and caspase-3. Consistent with enhancement of caspase activity, LSGE increased protein levels of cleaved caspase-3, caspase-8, caspase-9, and poly-ADP-ribose polymerase (PARP). These apoptotic effects of LSGE were inhibited by the pan-caspase inhibitor Z-VAD-fmk. These findings indicate that LSGE inhibits NCI-H460 human lung cancer cell growth by cell cycle arrest at the G0/G1 phase and induction of caspase-mediated apoptosis.-
dc.publisherSpringer-
dc.titleLipid-soluble ginseng extract induces apoptosis and G0/G1 cell cycle arrest in NCI-H460 human lung cancer cells-
dc.title.alternativeLipid-soluble ginseng extract induces apoptosis and G0/G1 cell cycle arrest in NCI-H460 human lung cancer cells-
dc.typeArticle-
dc.citation.titlePlant Foods for Human Nutrition-
dc.citation.number2-
dc.citation.endPage106-
dc.citation.startPage101-
dc.citation.volume66-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName강무림-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName이기호-
dc.contributor.alternativeName이성동-
dc.contributor.alternativeName현동훈-
dc.contributor.alternativeName인만진-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName김동청-
dc.identifier.bibliographicCitationPlant Foods for Human Nutrition, vol. 66, no. 2, pp. 101-106-
dc.identifier.doi10.1007/s11130-011-0232-6-
dc.subject.keywordApoptosis induction-
dc.subject.keywordCaspase activation-
dc.subject.keywordG0/G1 phase arrest-
dc.subject.keywordHuman lung cancer cell-
dc.subject.keywordLipid-soluble ginseng extract-
dc.subject.localapoptosis induction-
dc.subject.localApoptosis induction-
dc.subject.localCaspase activation-
dc.subject.localcaspase activation-
dc.subject.localG0/G1 phase arrest-
dc.subject.localHuman lung cancer cell-
dc.subject.localLipid-soluble ginseng extract-
dc.subject.locallipid-soluble ginseng extract-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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