DC Field | Value | Language |
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dc.contributor.author | D H Kwak | - |
dc.contributor.author | B S Seo | - |
dc.contributor.author | Kyu Tae Chang | - |
dc.contributor.author | Y K Choo | - |
dc.date.accessioned | 2017-04-19T09:24:40Z | - |
dc.date.available | 2017-04-19T09:24:40Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | I000-0028 | - |
dc.identifier.uri | 10.3858/emm.2011.43.7.048 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10256 | - |
dc.description.abstract | Gangliosides have been suggested to play important roles in various functions such as adhesion, cell differentiation, growth control, and signaling. Mouse follicular development, ovulation, and luteinization during the estrous cycle are regulated by several hormones and cell-cell interactions. In addition, spermatogenesis in seminiferous tubules of adult testes is also regulated by several hormones, including follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and cell-cell interactions. The regulation of these processes by hormones and cell-cell interactions provides evidence for the importance of surface membrane components, including gangliosides. During preimplantation embryo development, a mammalian embryo undergoes a series of cleavage divisions whereby a zygote is converted into a blastocyst that is sufficiently competent to be implanted in the maternal uterus and continue its development. Mouse embryonic stem (mES) cells are pluripotent cells derived from mouse embryo, specifically, from the inner cell mass of blastocysts. Differentiated neuronal cells are derived from mES cells through the formation of embryonic bodies (EBs). EBs recapitulate many aspects of lineage-specific differentiation and temporal and spatial gene expression patterns during early embryogenesis. Previous studies on ganglioside expression during mouse embryonic development (including during in vitro fertilization, ovulation, spermatogenesis, and embryogenesis) reported that gangliosides were expressed in both undifferentiated and differentiated (or differentiating) mES cells. In this review, we summarize some of the advances in our understanding of the functional roles of gangliosides during the stages of mouse embryonic development, including ovulation, spermatogenesis, and embryogenesis, focusing on undifferentiated and differentiated mES cells (neuronal cells). | - |
dc.publisher | Springer-Nature Pub Group | - |
dc.title | Roles of gangliosides in mouse embryogenesis and embryonic stem cell differentiation | - |
dc.title.alternative | Roles of gangliosides in mouse embryogenesis and embryonic stem cell differentiation | - |
dc.type | Article | - |
dc.citation.title | Experimental and Molecular Medicine | - |
dc.citation.number | 7 | - |
dc.citation.endPage | 388 | - |
dc.citation.startPage | 379 | - |
dc.citation.volume | 43 | - |
dc.contributor.affiliatedAuthor | Kyu Tae Chang | - |
dc.contributor.alternativeName | 곽동훈 | - |
dc.contributor.alternativeName | 서병부 | - |
dc.contributor.alternativeName | 장규태 | - |
dc.contributor.alternativeName | 추영국 | - |
dc.identifier.bibliographicCitation | Experimental and Molecular Medicine, vol. 43, no. 7, pp. 379-388 | - |
dc.identifier.doi | 10.3858/emm.2011.43.7.048 | - |
dc.subject.keyword | Cell differentiation | - |
dc.subject.keyword | Embryonic development | - |
dc.subject.keyword | Embryonic stem cells | - |
dc.subject.keyword | Gangliosides | - |
dc.subject.keyword | Ovulation | - |
dc.subject.keyword | Spermatogenesis | - |
dc.subject.local | cell differentiation | - |
dc.subject.local | Cell differentiation | - |
dc.subject.local | Embryonic development | - |
dc.subject.local | embryonic development | - |
dc.subject.local | embryonic stem cell | - |
dc.subject.local | embryonic stem cells | - |
dc.subject.local | Embryonic stem cell | - |
dc.subject.local | Embryonic stem cells | - |
dc.subject.local | embryonic stem cell (ESC) | - |
dc.subject.local | Ganglioside | - |
dc.subject.local | Gangliosides | - |
dc.subject.local | ganglioside | - |
dc.subject.local | Ovulation | - |
dc.subject.local | Spermatogenesis | - |
dc.subject.local | spermatogenesis | - |
dc.description.journalClass | Y | - |
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