Effect of the isosteric replacement of the phenyl motif with furyl (or thienyl) of 4-phenyl-N-arylsulfonylimidazolones as broad and potent anticancer agents

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dc.contributor.authorV K Sharma-
dc.contributor.authorD T Hung-
dc.contributor.authorK C Lee-
dc.contributor.authorP Thanigaimalai-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorHwan Mook Kim-
dc.contributor.authorS H Jung-
dc.date.accessioned2017-04-19T09:24:51Z-
dc.date.available2017-04-19T09:24:51Z-
dc.date.issued2011-
dc.identifier.issn2040-2503-
dc.identifier.uri10.1039/c0md00219dko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10278-
dc.description.abstractTo investigate the effect of isosteric replacement of phenyl with heteroaromatics of 4-phenyl-N-arylsulfonylimidazolones (1-4) as broad and potent anticancer agents, a series of 4-furyl (5a-e, 7a-c) or thienyl-N- arylsulfonylimidazolones (6a-e) were designed and synthesized to evaluate their in vitro anticancer activity against HCT116, A549 and NCI-H460 cancer cell lines. Replacement of phenyl with furyl or thienyl slightly reduced the activity, however, these analogs showed comparable activity to doxorubicin. The thienyl analogs exhibited more potent activity than furyl analogs due to their more isosteric similarity with the phenyl moiety. In addition, the carbamate derivatives (5a-e and 6a-e) of both the analogs had better activities than the carbamoyl derivatives (7a-c). Therefore, the size and planarity of the aryl motif at 4-position of N-arylsulfonylimidazolones are crucial for their anticancer activity.-
dc.publisherRoyal Soc Chemistry-
dc.titleEffect of the isosteric replacement of the phenyl motif with furyl (or thienyl) of 4-phenyl-N-arylsulfonylimidazolones as broad and potent anticancer agents-
dc.title.alternativeEffect of the isosteric replacement of the phenyl motif with furyl (or thienyl) of 4-phenyl-N-arylsulfonylimidazolones as broad and potent anticancer agents-
dc.typeArticle-
dc.citation.titleMedchemcomm-
dc.citation.number8-
dc.citation.endPage734-
dc.citation.startPage731-
dc.citation.volume2-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.alternativeNameSharma-
dc.contributor.alternativeNameHung-
dc.contributor.alternativeName이기철-
dc.contributor.alternativeNameThanigaimalai-
dc.contributor.alternativeName강종성-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName정상훈-
dc.identifier.bibliographicCitationMedchemcomm, vol. 2, no. 8, pp. 731-734-
dc.identifier.doi10.1039/c0md00219d-
dc.description.journalClassN-
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