Small-molecule-based nanoassemblies as inducible nanoprobes for monitoring dynamic molecular interactions inside live cells

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Title
Small-molecule-based nanoassemblies as inducible nanoprobes for monitoring dynamic molecular interactions inside live cells
Author(s)
S Lee; K H Lee; J S Ha; Seung Goo Lee; T K Kim
Bibliographic Citation
Angewandte Chemie-International Edition, vol. 50, no. 37, pp. 8709-8713
Publication Year
2011
Abstract
Seeing into cells: Genetically engineered, labeled ferritin is used to form biological nanoparticles displaying bait (B) and prey (P) molecules inside cells (see picture). Specific bait-prey interactions induce the interconnected assembly of nanoparticles into nanoclusters on a timescale of seconds. This phenotypic readout with a small molecule as an inducible switch was used to directly visualize dynamic molecular interactions within living cells.
Keyword
fluorescencemolecular interactionsnanoassembliesnanoparticlesproteins
ISSN
1433-7851
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/anie.201101467
Type
Article
Appears in Collections:
Synthetic Biology and Bioengineering Research Institute > 1. Journal Articles
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