CMOS image sensor for detection of interferon gamma protein interaction as a point-of-care approach

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dc.contributor.authorM Marimuthu-
dc.contributor.authorK Kandasamy-
dc.contributor.authorC G Ahn-
dc.contributor.authorG Y Sung-
dc.contributor.authorMin-Gon Kim-
dc.contributor.authorS Kim-
dc.date.accessioned2017-04-19T09:25:17Z-
dc.date.available2017-04-19T09:25:17Z-
dc.date.issued2011-
dc.identifier.issn1618-2642-
dc.identifier.uri10.1007/s00216-011-5231-9ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10308-
dc.description.abstractComplementary metal oxide semiconductor (CMOS)-based image sensors have received increased attention owing to the possibility of incorporating them into portable diagnostic devices. The present research examined the efficiency and sensitivity of a CMOS image sensor for the detection of antigen-antibody interactions involving interferon gamma protein without the aid of expensive instruments. The highest detection sensitivity of about 1 fg/ml primary antibody was achieved simply by a transmission mechanism. When photons are prevented from hitting the sensor surface, a reduction in digital output occurs in which the number of photons hitting the sensor surface is approximately proportional to the digital number. Nanoscale variation in substrate thickness after protein binding can be detected with high sensitivity by the CMOS image sensor. Therefore, this technique can be easily applied to smartphones or any clinical diagnostic devices for the detection of several biological entities, with high impact on the development of point-of-care applications.-
dc.publisherSpringer-
dc.titleCMOS image sensor for detection of interferon gamma protein interaction as a point-of-care approach-
dc.title.alternativeCMOS image sensor for detection of interferon gamma protein interaction as a point-of-care approach-
dc.typeArticle-
dc.citation.titleAnalytical and Bioanalytical Chemistry-
dc.citation.number5-
dc.citation.endPage1653-
dc.citation.startPage1645-
dc.citation.volume401-
dc.contributor.affiliatedAuthorMin-Gon Kim-
dc.contributor.alternativeNameMarimuthu-
dc.contributor.alternativeNameKandasamy-
dc.contributor.alternativeName안창근-
dc.contributor.alternativeName성건용-
dc.contributor.alternativeName김민곤-
dc.contributor.alternativeName김상효-
dc.identifier.bibliographicCitationAnalytical and Bioanalytical Chemistry, vol. 401, no. 5, pp. 1645-1653-
dc.identifier.doi10.1007/s00216-011-5231-9-
dc.subject.keywordCMOS sensors-
dc.subject.keywordImmunoassays-
dc.subject.keywordIndium nanoparticles-
dc.subject.keywordInterferon gamma-
dc.subject.keywordPhoton-
dc.subject.localCMOS sensors-
dc.subject.localImmunoassay-
dc.subject.localImmunoassays-
dc.subject.localimmunoassay-
dc.subject.localIndium nanoparticles-
dc.subject.localInterferon γ-
dc.subject.localinterferon-γ-
dc.subject.localInterferon-γ-
dc.subject.localinterferon-gamma-
dc.subject.localInterferon gamma-
dc.subject.localPhoton-
dc.description.journalClassY-
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