5-(4-Hydroxy-2,3,5-trimethylbenzylidene) thiazolidine-2,4-dione attenuates atherosclerosis possibly by reducing monocyte recruitment to the lesion

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dc.contributor.authorJ H Choi-
dc.contributor.authorJong Gil Park-
dc.contributor.authorH J Jeon-
dc.contributor.authorM S Kim-
dc.contributor.authorM R Lee-
dc.contributor.authorM N Lee-
dc.contributor.authorS K Sonn-
dc.contributor.authorJ H Kim-
dc.contributor.authorM H Lee-
dc.contributor.authorM S Choi-
dc.contributor.authorY B Park-
dc.contributor.authorO S Kwon-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorWoo Song Lee-
dc.contributor.authorH B Shim-
dc.contributor.authorD H Shin-
dc.contributor.authorG T Oh-
dc.date.accessioned2017-04-19T09:25:19Z-
dc.date.available2017-04-19T09:25:19Z-
dc.date.issued2011-
dc.identifier.issnI0000028-
dc.identifier.uri10.3858/emm.2011.43.8.053ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10309-
dc.description.abstractA variety of benzylidenethiazole analogs have been demonstrated to inhibit 5-lipoxygenase (5-LOX). Here we report the anti-atherogenic potential of 5-(4-hydroxy-2,3,5-trimethylbenzylidene) thiazolidin-2,4-dione (HMB-TZD), a benzylidenethiazole analog, and its potential mechanism of action in LDL receptor-deficient (Ldlr-/-) mice. HMB-TZD Treatment reduced leukotriene B4 (LTB4) production significantly in RAW264.7 macrophages and SVEC4-10 endothelial cells. Macrophages or endothelial cells pre-incubated with HMB-TZD for 2 h and then stimulated with lipopolysaccharide or tumor necrosis factor-alpha (TNF-α) displayed reduced cytokine production. Also, HMB-TZD reduced cell migration and adhesion in accordance with decreased proinflammatory molecule production in vitro and ex vivo. HMB-TZD treatment of 8-week-old male Ldlr-/- mice resulted in significantly reduced atherosclerotic lesions without a change to plasma lipid profiles. Moreover, aortic expression of pro-atherogenic molecules involved in the recruitment of monocytes to the aortic wall, including TNF-α, MCP-1, and VCAM-1, was downregulated. HMB-TZD also reduced macrophage infiltration into atherosclerotic lesions. In conclusion, HMB-TZD ameliorates atherosclerotic lesion formation possibly by reducing the expression of proinflammatory molecules and monocyte/macrophage recruitment to the lesion. These results suggest that HMB-TZD, and benzylidenethiazole analogs in general, may have therapeutic potential as treatments for atherosclerosis.-
dc.publisherSpringer-Nature Pub Group-
dc.title5-(4-Hydroxy-2,3,5-trimethylbenzylidene) thiazolidine-2,4-dione attenuates atherosclerosis possibly by reducing monocyte recruitment to the lesion-
dc.title.alternative5-(4-Hydroxy-2,3,5-trimethylbenzylidene) thiazolidine-2,4-dione attenuates atherosclerosis possibly by reducing monocyte recruitment to the lesion-
dc.typeArticle-
dc.citation.titleExperimental and Molecular Medicine-
dc.citation.number8-
dc.citation.endPage478-
dc.citation.startPage471-
dc.citation.volume43-
dc.contributor.affiliatedAuthorJong Gil Park-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName최재훈-
dc.contributor.alternativeName박종길-
dc.contributor.alternativeName전형준-
dc.contributor.alternativeName김미순-
dc.contributor.alternativeName이미란-
dc.contributor.alternativeName이미니-
dc.contributor.alternativeName손성근-
dc.contributor.alternativeName김재홍-
dc.contributor.alternativeName이문한-
dc.contributor.alternativeName최명숙-
dc.contributor.alternativeName박용복-
dc.contributor.alternativeName권오승-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName심현보-
dc.contributor.alternativeName신동해-
dc.contributor.alternativeName오구택-
dc.identifier.bibliographicCitationExperimental and Molecular Medicine, vol. 43, no. 8, pp. 471-478-
dc.identifier.doi10.3858/emm.2011.43.8.053-
dc.subject.keywordAntioxidants-
dc.subject.keywordArachidonate 5-lipoxygenase-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordEndothelial cells-
dc.subject.keywordMacrophages-
dc.subject.localAntioxidants-
dc.subject.localAntioxidant-
dc.subject.localArachidonate 5-lipoxygenase-
dc.subject.localAtherosclerosis-
dc.subject.localEndothelial cells-
dc.subject.localEndothelial cell-
dc.subject.localMacrophages-
dc.subject.localMacrophage-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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