Inhibitory effects on nuclear factor jB of the Vietnamese freshwater cyanobacteria

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Title
Inhibitory effects on nuclear factor jB of the Vietnamese freshwater cyanobacteria
Author(s)
T D Nguyen; T T Duong; T P Q Le; V M Chau; M H Le; D K Dang; Jung Joon Lee; M L Bourguet-Kondracki
Bibliographic Citation
Medicinal Chemistry Research, vol. 20, no. 6, pp. 790-793
Publication Year
2011
Abstract
Several Vietnamese freshwater cyanobacteria were collected and evaluated for their effects on the transcriptional nuclear factor κB (NF-κB) which are involving in the cancer and inflammatory diseases. Five extraction conditions were tested and a solution of 2% acetic acid in methanol provided highest yield of extract from bacterial biomass. The Microcystis aeruginosa TC-1 and TC-3 strains showed strong NF-κB inhibitory activity with IC 50 values of 6.1 and 5.3 μg/ml, respectively. Moreover, all tested cyanobacteriaexhibited cytotoxicity on human cervical cancer HeLa cells in a dose-dependent manner. Ergosterol (1) isolated from M. aeruginosa TC-3 strains strongly inhibited NF-κB activation with IC50 values of 0.91 μg/ml.
Keyword
Anabaena spCyanobacteriaCytotoxicityMicrocystis aeruginosaNF-κB
ISSN
1054-2523
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s00044-010-9409-z
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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