Interspecies transmission of the canine influenza H3N2 virus to domestic cats in South Korea, 2010

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Title
Interspecies transmission of the canine influenza H3N2 virus to domestic cats in South Korea, 2010
Author(s)
Dae Sub Song; D J An; H J Moon; M J Yeom; H Y Jung; W S Jung; S J Park; Hye Kwon Kim; S Y Han; J S Oh; B K Park; Jeong Ki Kim; Haryoung Poo; R G Webster; K Jung; B K Kang
Bibliographic Citation
Journal of General Virology, vol. 92, no. 10, pp. 2350-2355
Publication Year
2011
Abstract
In the past 4 years, incidences of endemic or epidemic respiratory diseases associated with canine influenza H3N2 virus in Asian dogs have been reported in countries such as South Korea and China. Canine species were considered to be the new natural hosts for this virus. However, at the beginning of 2010, influenza-like respiratory signs, such as dyspnoea, were also observed among cats as well as in dogs in an animal shelter located in Seoul, South Korea. The affected cats showed 100% morbidity and 40% mortality. We were able to isolate a virus from a lung specimen of a dead cat, which had suffered from the respiratory disease, in embryonated-chicken eggs. The eight viral genes isolated were almost identical to those of the canine influenza H3N2 virus, suggesting interspecies transmission of canine influenza H3N2 virus to the cat. Moreover, three domestic cats infected with intranasal canine/Korea/GCVP01/07 (H3N2) all showed elevated rectal temperatures, nasal virus shedding and severe pulmonary lesions, such as suppurative bronchopneumonia. Our study shows, for the first time, that cats are susceptible to canine influenza H3N2 infection, suggesting that cats may play an intermediate host role in transmitting the H3N2 virus among feline and canine species, which could lead to the endemic establishment of the virus in companion animals. Such a scenario raises a public health concern, as the possibility of the emergence of new recombinant feline or canine influenza viruses in companion animals with the potential to act as a zoonotic infection cannot be excluded.
ISSN
0022-1317
Publisher
Microbiology Soc
DOI
http://dx.doi.org/10.1099/vir.0.033522-0
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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