The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis

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dc.contributor.authorD H Lim-
dc.contributor.authorC T Oh-
dc.contributor.authorL Lee-
dc.contributor.authorJ S Hong-
dc.contributor.authorS H Noh-
dc.contributor.authorSeungwoo Hwang-
dc.contributor.authorS Kim-
dc.contributor.authorS J Han-
dc.contributor.authorY S Lee-
dc.date.accessioned2017-04-19T09:25:24Z-
dc.date.available2017-04-19T09:25:24Z-
dc.date.issued2011-
dc.identifier.issn0014-5793-
dc.identifier.uri10.1016/j.febslet.2011.08.034ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10326-
dc.description.abstractSmall non-coding RNAs regulate gene expression in a sequence-specific manner. In Drosophila, Dicer-2 (Dcr-2) functions in the biogenesis of endogenous small interfering RNAs (endo-siRNAs). We identified 21 distinct proteins that exhibited a ≥1.5-fold change as a consequence of loss of dcr-2 function. Most of these were metabolic genes implicated in stress resistance and aging. dcr-2 Mutants had reduced lifespan and were hypersensitive to oxidative, endoplasmic reticulum, starvation, and cold stresses. Furthermore, loss of dcr-2 function led to abnormal lipid and carbohydrate metabolism. Our results suggest roles for the endo-siRNA pathway in metabolic regulation and defense against stress and aging in Drosophila.-
dc.publisherWiley-
dc.titleThe endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis-
dc.title.alternativeThe endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis-
dc.typeArticle-
dc.citation.titleFEBS Letters-
dc.citation.number19-
dc.citation.endPage3085-
dc.citation.startPage3079-
dc.citation.volume585-
dc.contributor.affiliatedAuthorSeungwoo Hwang-
dc.contributor.alternativeName임도환-
dc.contributor.alternativeName오춘택-
dc.contributor.alternativeName이랑호-
dc.contributor.alternativeName홍재상-
dc.contributor.alternativeName노수현-
dc.contributor.alternativeName황승우-
dc.contributor.alternativeName김성찬-
dc.contributor.alternativeName한성준-
dc.contributor.alternativeName이영식-
dc.identifier.bibliographicCitationFEBS Letters, vol. 585, no. 19, pp. 3079-3085-
dc.identifier.doi10.1016/j.febslet.2011.08.034-
dc.subject.keywordDicer-2-
dc.subject.keywordDrosophila-
dc.subject.keywordEndogenous siRNA-
dc.subject.keywordLifespan-
dc.subject.keywordMetabolic homeostasis-
dc.subject.keywordStress response-
dc.subject.localDicer-2-
dc.subject.localdrosophila-
dc.subject.localDrosophila-
dc.subject.localEndogenous siRNA-
dc.subject.localEndogenous sirna-
dc.subject.locallifespan-
dc.subject.localLifespan-
dc.subject.localMetabolic homeostasis-
dc.subject.localmetabolic homeostasis-
dc.subject.localMetabolic Homeostasis-
dc.subject.localStress response-
dc.description.journalClassY-
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