DC Field | Value | Language |
---|---|---|
dc.contributor.author | D H Lim | - |
dc.contributor.author | C T Oh | - |
dc.contributor.author | L Lee | - |
dc.contributor.author | J S Hong | - |
dc.contributor.author | S H Noh | - |
dc.contributor.author | Seungwoo Hwang | - |
dc.contributor.author | S Kim | - |
dc.contributor.author | S J Han | - |
dc.contributor.author | Y S Lee | - |
dc.date.accessioned | 2017-04-19T09:25:24Z | - |
dc.date.available | 2017-04-19T09:25:24Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | 10.1016/j.febslet.2011.08.034 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10326 | - |
dc.description.abstract | Small non-coding RNAs regulate gene expression in a sequence-specific manner. In Drosophila, Dicer-2 (Dcr-2) functions in the biogenesis of endogenous small interfering RNAs (endo-siRNAs). We identified 21 distinct proteins that exhibited a ≥1.5-fold change as a consequence of loss of dcr-2 function. Most of these were metabolic genes implicated in stress resistance and aging. dcr-2 Mutants had reduced lifespan and were hypersensitive to oxidative, endoplasmic reticulum, starvation, and cold stresses. Furthermore, loss of dcr-2 function led to abnormal lipid and carbohydrate metabolism. Our results suggest roles for the endo-siRNA pathway in metabolic regulation and defense against stress and aging in Drosophila. | - |
dc.publisher | Wiley | - |
dc.title | The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis | - |
dc.title.alternative | The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis | - |
dc.type | Article | - |
dc.citation.title | FEBS Letters | - |
dc.citation.number | 19 | - |
dc.citation.endPage | 3085 | - |
dc.citation.startPage | 3079 | - |
dc.citation.volume | 585 | - |
dc.contributor.affiliatedAuthor | Seungwoo Hwang | - |
dc.contributor.alternativeName | 임도환 | - |
dc.contributor.alternativeName | 오춘택 | - |
dc.contributor.alternativeName | 이랑호 | - |
dc.contributor.alternativeName | 홍재상 | - |
dc.contributor.alternativeName | 노수현 | - |
dc.contributor.alternativeName | 황승우 | - |
dc.contributor.alternativeName | 김성찬 | - |
dc.contributor.alternativeName | 한성준 | - |
dc.contributor.alternativeName | 이영식 | - |
dc.identifier.bibliographicCitation | FEBS Letters, vol. 585, no. 19, pp. 3079-3085 | - |
dc.identifier.doi | 10.1016/j.febslet.2011.08.034 | - |
dc.subject.keyword | Dicer-2 | - |
dc.subject.keyword | Drosophila | - |
dc.subject.keyword | Endogenous siRNA | - |
dc.subject.keyword | Lifespan | - |
dc.subject.keyword | Metabolic homeostasis | - |
dc.subject.keyword | Stress response | - |
dc.subject.local | Dicer-2 | - |
dc.subject.local | drosophila | - |
dc.subject.local | Drosophila | - |
dc.subject.local | Endogenous siRNA | - |
dc.subject.local | Endogenous sirna | - |
dc.subject.local | lifespan | - |
dc.subject.local | Lifespan | - |
dc.subject.local | Metabolic homeostasis | - |
dc.subject.local | metabolic homeostasis | - |
dc.subject.local | Metabolic Homeostasis | - |
dc.subject.local | Stress response | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.