L1 cell adhesion molecule as a novel independent poor prognostic factor in gallbladder carcinoma

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Title
L1 cell adhesion molecule as a novel independent poor prognostic factor in gallbladder carcinoma
Author(s)
S Y Choi; Y S Jo; S M Huang; Z L Liang; Jeong Ki Min; H J Hong; J M Kim
Bibliographic Citation
Human Pathology, vol. 42, no. 10, pp. 1476-1483
Publication Year
2011
Abstract
Gallbladder carcinoma is a lethal malignancy and is hard to cure by current treatment. Thus, identification of molecular prognostic markers to predict gallbladder carcinoma as therapeutic targets is urgently needed. Recent studies have demonstrated that L1 cell adhesion molecule is associated with the prognosis of variable malignancy. Here, we investigated L1 cell adhesion molecule expression in gallbladder carcinoma and its prognostic significance. In this study, we examined L1 cell adhesion molecule expression in tumor specimens from 69 patients with gallbladder carcinoma by immunohistochemistry and analyzed the correlation between L1 cell adhesion molecule expression and clinicopathologic factors or survival. L1 cell adhesion molecule was not expressed in the normal epithelium of the gallbladder but in 63.8% of gallbladder carcinomas, remarkably at the invasive front of the tumors. In addition, L1 cell adhesion molecule expression was significantly associated with high histologic grade, advanced pathologic T stage and clinical stage, and positive venous/lymphatic invasion. Multivariate analyses showed that L1 cell adhesion molecule expression (hazard ratio, 3.503; P =.028) and clinical stage (hazard ratio, 3.091; P =.042) were independent risk factor for disease-free survival. L1 cell adhesion molecule expression in gallbladder carcinoma was significantly correlated with tumor progression and unfavorable clinicopathologic features. L1 cell adhesion molecule expression was an independent poor prognostic factor for disease-free survival in patients with gallbladder carcinoma. Taken together, our findings suggest that L1 cell adhesion molecule expression could be used as a novel prognostic factor for patient survival and might be a potential therapeutic target in gallbladder carcinomas.
Keyword
Gallbladder carcinomaL1 cell adhesion moleculePrognosisSurvival analysis
ISSN
0046-8177
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.humpath.2011.01.003
Type
Article
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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