IL-15-induced IL-10 increases the cytolytic activity of human natural killer cells

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Title
IL-15-induced IL-10 increases the cytolytic activity of human natural killer cells
Author(s)
J Y Park; S H Lee; Suk Ran YoonYoung-Jun ParkHaiyoung JungTae-Don KimIn Pyo Choi
Bibliographic Citation
Molecules and Cells, vol. 32, no. 3, pp. 265-272
Publication Year
2011
Abstract
Interleukin 10 (IL-10) is a multifunctional cytokine that regulates diverse functions of immune cells. Natural killer (NK) cells express the IL-10 and IL-10 receptor, but little is known about the function of IL-10 on NK cell activation. In this study, we show the expression and role of IL-10 in human NK cells. Among the cytokines tested, IL-15 was the most potent inducer of IL-10, with a maximal peak expression at 5 h after treatment. Furthermore, IL-10 receptor was shown to be expressed in NK cells. IL-10 alone had a significant effect on NK cytotoxicity which additively increased NK cell cytotoxicity in the presence of IL-15. Neutralizing IL-10 with anti-IL-10 antibody suppressed the inductive effect of IL-10 on NK cell cytotoxicity; however, IL- 10 had no effect on IFN- or TNF-a production or NK cell activatory receptor expression. STAT signals are implicated as a key mediator of IL-10/IL-15 cytotoxicity response. Thus, the effect of IL-10 on NK cells is particularly interesting with regard to the STAT3 signal that was enhanced by IL-10 or IL-15.
Keyword
CytotoxicityIL-10IL-15Natural killer cell
ISSN
1016-8478
Publisher
South Korea
DOI
http://dx.doi.org/10.1007/s10059-011-1057-8
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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