Direct one-pot introduction of 2-methylpyridines to Baylis-Hillman adducts via base-mediated 3-aza-Cope rearrangement

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Title
Direct one-pot introduction of 2-methylpyridines to Baylis-Hillman adducts via base-mediated 3-aza-Cope rearrangement
Author(s)
H S Lee; Sangku Lee; S H Kim; J N Kim
Bibliographic Citation
Tetrahedron Letters, vol. 52, no. 39, pp. 5039-5042
Publication Year
2011
Abstract
An efficient and regioselective introduction method of 2-methylpyridines to the secondary position of Baylis-Hillman adducts has been developed. A base treatment of 2-methylpyridinium salt of Baylis-Hillman bromide generated N-allylenamine intermediate which underwent a facile 3-aza-Cope rearrangement under mild conditions to produce the product.
Keyword
2-MethylpyridinesAza-Cope rearrangementBaylis-Hillman adducts
ISSN
0040-4039
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.tetlet.2011.07.101
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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