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- Title
- Direct one-pot introduction of 2-methylpyridines to Baylis-Hillman adducts via base-mediated 3-aza-Cope rearrangement
- Author(s)
- H S Lee; Sangku Lee; S H Kim; J N Kim
- Bibliographic Citation
- Tetrahedron Letters, vol. 52, no. 39, pp. 5039-5042
- Publication Year
- 2011
- Abstract
- An efficient and regioselective introduction method of 2-methylpyridines to the secondary position of Baylis-Hillman adducts has been developed. A base treatment of 2-methylpyridinium salt of Baylis-Hillman bromide generated N-allylenamine intermediate which underwent a facile 3-aza-Cope rearrangement under mild conditions to produce the product.
- Keyword
- 2-MethylpyridinesAza-Cope rearrangementBaylis-Hillman adducts
- ISSN
- 0040-4039
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.1016/j.tetlet.2011.07.101
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
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