Syntheses of sulfur and selenium analogues of pachastrissamine via double displacements of cyclic sulfate = 고리형 설페이트의 이중 치환을 이용한 파카스크리사민 유도체의 합성

Abstract

Bioisosteric analogues of pachastrissamine that contain sulfur and selenium atoms replacing the oxygen in the ring system, were efficiently prepared from a cyclic sulfate intermediate by sequential intermolecular and intramolecular S N2 displacement reactions of the dianions. The analogues exhibited cytotoxicities comparable to that of pachastrissamine.