Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL/6J mice

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Title
Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL/6J mice
Author(s)
G M Do; Hea-Young Oh; E Y Kwon; Y Y Cho; S K Shin; H J Park; S M Jeon; E Kim; Cheol-Goo Hur; T S Park; M K Sung; R A McGregor; M S Choi
Bibliographic Citation
Molecular Nutrition & Food Research, vol. 55, no. S2, pp. S173-S185
Publication Year
2011
Abstract
This study investigated the global transcriptional and metabolic changes occurring at multiple time points over 24wk in response to a high-fat diet (HFD). Methods and results: C57BL/6J mice were fed a HFD or normal diet (ND) over 24 wk. HFD-fed mice developed early clinical indicators of obesity-related co-morbidities including fatty liver, insulin resistance, hyperglycemia and hypercholesterolemia. Time-course microarray analysis at eight time points over 24 wk identified 332 HFD responsive genes as potential targets to counteract diet-induced obesity (DIO) and related co-morbidities. Glucose regulating enzyme activity and gene expression were altered early in the HFD-fed mice. Fatty acid (FA) and triglyceride (TG) accumulation in combination with inflammatory changes appear to be likely candidates contributing to hepatic insulin resistance. Cidea seemed to be one of representative genes related to these changes. Conclusion: Global transcriptional and metabolic profiling across multiple time points in liver revealed potential targets for nutritional interventions to reverse DIO. In future, new approaches targeting HFD responsive genes and hepatic metabolism could help ameliorate the deleterious effects of an HFD and DIO-related complication.
Keyword
Diet-induced obesityInsulin resistanceMetabolic profileMicroarrayTranscriptional response
ISSN
1613-4125
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/mnfr.201100064
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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