Synthesis of 2,4,6-tripyridyl pyridines, and evaluation of their antitumor cytotoxicity, topoisomerase I and II inhibitory activity, and structure-activity relationship = 삼중피리딘 화합물의 항암효과, topoisomerase 활성 억제 효과, 구조 활성 관계

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Title
Synthesis of 2,4,6-tripyridyl pyridines, and evaluation of their antitumor cytotoxicity, topoisomerase I and II inhibitory activity, and structure-activity relationship = 삼중피리딘 화합물의 항암효과, topoisomerase 활성 억제 효과, 구조 활성 관계
Author(s)
B S Jeong; H Choi; Young Shin Kwak; E S Lee
Bibliographic Citation
Bulletin of Korean Chemical Society, vol. 32, no. 10, pp. 3566-3570
Publication Year
2011
Abstract
A series of 2,4,6-tripyridyl pyridines were synthesized, and evaluated for their antitumor cytotoxicity, topoisomerase I and II inhibitory activity. From the eighteen prepared compounds, compounds 10-12 have shown better or similar cytotoxicity against several human cancer cell lines as compared to 2,2':6',2''- terpyridine and doxorubicin. Especially, compound 10 exhibited the most potent cytotoxicity better than positive controls. Structure-activity relationship study indicated that 2,2':6',2''-terpyridine skeleton has an important role in displaying significant cytotoxicity against several human cancer cell lines.
Keyword
2,4,6-Tripyridyl pyridineCytotoxicitySAR studyTerpyridineTopoisomerase inhibition
ISSN
0253-2964
Publisher
Wiley
DOI
http://dx.doi.org/10.5012/bkcs.2011.32.10.3566
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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