Synthesis of 2,4,6-tripyridyl pyridines, and evaluation of their antitumor cytotoxicity, topoisomerase I and II inhibitory activity, and structure-activity relationship = 삼중피리딘 화합물의 항암효과, topoisomerase 활성 억제 효과, 구조 활성 관계

Abstract

A series of 2,4,6-tripyridyl pyridines were synthesized, and evaluated for their antitumor cytotoxicity, topoisomerase I and II inhibitory activity. From the eighteen prepared compounds, compounds 10-12 have shown better or similar cytotoxicity against several human cancer cell lines as compared to 2,2':6',2''- terpyridine and doxorubicin. Especially, compound 10 exhibited the most potent cytotoxicity better than positive controls. Structure-activity relationship study indicated that 2,2':6',2''-terpyridine skeleton has an important role in displaying significant cytotoxicity against several human cancer cell lines.