Transcriptional variations mediated by an alternative promoter of the FPR3 gene = FPR3 유전자의 alternative promoter에 따른 transcriptional variation

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Title
Transcriptional variations mediated by an alternative promoter of the FPR3 gene = FPR3 유전자의 alternative promoter에 따른 transcriptional variation
Author(s)
H S Ha; Jae Won Huh; J A Gim; K Han; H S Kim
Bibliographic Citation
Mammalian Genome, vol. 22, no. 9, pp. 621-633
Publication Year
2011
Abstract
Formyl peptide receptor 3 (FPR3) is a potential player in innate immunity and appears with FPR2 as a FPR cluster during primate evolution. Comparative genome analyses indicate that a segmental duplication (SD) event upstream of the FPR3 gene after the divergence of New and Old World monkeys led to the emergence of an alternative promoter. In this study we combined computational and experimental approaches to identify a FPR3 gene that is controlled by an alternative promoter derived during a SD event. Its transcriptional activity was detected by quantitative reverse transcription polymerase chain reaction. Human alternative transcripts (FPR3-1 and FPR3-2) showed tissue-specific patterns with strong expressions in lung or uterus, while the FPR3-1 transcript of rhesus macaque is broadly expressed in various tissues. Overall, transcriptional variations of FPR3 occur by an alternative promoter during primate evolution.
ISSN
0938-8990
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s00335-011-9341-7
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
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