Transcriptional variations mediated by an alternative promoter of the FPR3 gene = FPR3 유전자의 alternative promoter에 따른 transcriptional variation

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dc.contributor.authorH S Ha-
dc.contributor.authorJae Won Huh-
dc.contributor.authorJ A Gim-
dc.contributor.authorK Han-
dc.contributor.authorH S Kim-
dc.date.accessioned2017-04-19T09:25:44Z-
dc.date.available2017-04-19T09:25:44Z-
dc.date.issued2011-
dc.identifier.issn0938-8990-
dc.identifier.uri10.1007/s00335-011-9341-7ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10374-
dc.description.abstractFormyl peptide receptor 3 (FPR3) is a potential player in innate immunity and appears with FPR2 as a FPR cluster during primate evolution. Comparative genome analyses indicate that a segmental duplication (SD) event upstream of the FPR3 gene after the divergence of New and Old World monkeys led to the emergence of an alternative promoter. In this study we combined computational and experimental approaches to identify a FPR3 gene that is controlled by an alternative promoter derived during a SD event. Its transcriptional activity was detected by quantitative reverse transcription polymerase chain reaction. Human alternative transcripts (FPR3-1 and FPR3-2) showed tissue-specific patterns with strong expressions in lung or uterus, while the FPR3-1 transcript of rhesus macaque is broadly expressed in various tissues. Overall, transcriptional variations of FPR3 occur by an alternative promoter during primate evolution.-
dc.publisherSpringer-
dc.titleTranscriptional variations mediated by an alternative promoter of the FPR3 gene = FPR3 유전자의 alternative promoter에 따른 transcriptional variation-
dc.title.alternativeTranscriptional variations mediated by an alternative promoter of the FPR3 gene-
dc.typeArticle-
dc.citation.titleMammalian Genome-
dc.citation.number9-
dc.citation.endPage633-
dc.citation.startPage621-
dc.citation.volume22-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.alternativeName하홍석-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName김정안-
dc.contributor.alternativeName한규동-
dc.contributor.alternativeName김희수-
dc.identifier.bibliographicCitationMammalian Genome, vol. 22, no. 9, pp. 621-633-
dc.identifier.doi10.1007/s00335-011-9341-7-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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