Expedient synthesis of 4-O-methylhonokiol via Suzuki-Miyaura cross-coupling = 스즈끼 반응을 이용한 메틸호노키올의 효율적 전합성

Abstract

Concise and practical synthesis of 4-O-methylhonokiol was achieved in 34% overall yield. The key features of our synthesis include chemoselective ortho-mono bromination of phenol as well as biaryl formation via Suzuki-Miyaura cross-coupling, in which bromophenol was reacted with potassium aryltrifluoroborate using Pd(OAc)2 and RuPhos under microwave conditions.