Expedient synthesis of 4-O-methylhonokiol via Suzuki-Miyaura cross-coupling = 스즈끼 반응을 이용한 메틸호노키올의 효율적 전합성

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Title
Expedient synthesis of 4-O-methylhonokiol via Suzuki-Miyaura cross-coupling = 스즈끼 반응을 이용한 메틸호노키올의 효율적 전합성
Author(s)
J H Kwak; Young Ae Cho; J Y Jang; S Y Seo; H Lee; J T Hong; S B Han; K Lee; Young Shin Kwak; J K Jung
Bibliographic Citation
Tetrahedron, vol. 67, no. 48, pp. 9401-9404
Publication Year
2011
Abstract
Concise and practical synthesis of 4-O-methylhonokiol was achieved in 34% overall yield. The key features of our synthesis include chemoselective ortho-mono bromination of phenol as well as biaryl formation via Suzuki-Miyaura cross-coupling, in which bromophenol was reacted with potassium aryltrifluoroborate using Pd(OAc)2 and RuPhos under microwave conditions.
Keyword
4-O-MethylhonokiolNeolignanPotassium aryltrifluoroborateSuzuki-Miyaura cross-coupling
ISSN
0040-4020
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.tet.2011.09.115
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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