DC Field | Value | Language |
---|---|---|
dc.contributor.author | M S Kim | - |
dc.contributor.author | Won Sam Kim | - |
dc.contributor.author | Z H Piao | - |
dc.contributor.author | Sohyun Yun | - |
dc.contributor.author | S H Lee | - |
dc.contributor.author | Su Ui Lee | - |
dc.contributor.author | M Jeong | - |
dc.contributor.author | H N Sun | - |
dc.contributor.author | Young-Jun Park | - |
dc.contributor.author | Haiyoung Jung | - |
dc.contributor.author | Suk Ran Yoon | - |
dc.contributor.author | In Pyo Choi | - |
dc.date.accessioned | 2017-04-19T09:25:45Z | - |
dc.date.available | 2017-04-19T09:25:45Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.uri | 10.1016/j.imlet.2011.07.007 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10378 | - |
dc.description.abstract | The IL-22 NKp46+ innate lymphoid cells, NCR22 cells, are very important for the early host defense against microbial pathogens. We show here that NCR22 cells were differentiated from Lin-CD127+CD117+ cells that were derived from hematopoietic precursor cells (HPCs) of mouse bone marrow cells. The combination of low concentrations of IL-23 and IL-15 induced differentiation of NCR22 cells from Lin-CD127+CD117+ cells. NCR22 cells expressed a large amount of IL-22 and RORγt, and they had poor cytolytic activity and produced little IFN-γ Lin-CD127+CD117+ cells were very similar to intestinal lamina propria LTi-like cells; both cells dominantly expressed RORγt and IL-22. Meanwhile, Lin-CD127-CD117+ cells that were also derived from HPCs did not express RORγt and IL-22, and they developed into conventional NK cells, not into NCR22 cells. These findings revealed that NCR22 cells can be differentiated from Lin-CD127+CD117+ cells which are derived from HPCs. | - |
dc.publisher | Elsevier | - |
dc.title | IL-22 producing NKp46+ innate lymphoid cells can differentiate from hematopoietic precursor cells = 조혈줄기세포로부터 IL-22를 생산하는 innate lymphoid cell의 분화 | - |
dc.title.alternative | IL-22 producing NKp46+ innate lymphoid cells can differentiate from hematopoietic precursor cells | - |
dc.type | Article | - |
dc.citation.title | Immunology Letters | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 67 | - |
dc.citation.startPage | 61 | - |
dc.citation.volume | 141 | - |
dc.contributor.affiliatedAuthor | Won Sam Kim | - |
dc.contributor.affiliatedAuthor | Sohyun Yun | - |
dc.contributor.affiliatedAuthor | Su Ui Lee | - |
dc.contributor.affiliatedAuthor | Young-Jun Park | - |
dc.contributor.affiliatedAuthor | Haiyoung Jung | - |
dc.contributor.affiliatedAuthor | Suk Ran Yoon | - |
dc.contributor.affiliatedAuthor | In Pyo Choi | - |
dc.contributor.alternativeName | 김미선 | - |
dc.contributor.alternativeName | 김원삼 | - |
dc.contributor.alternativeName | Piao | - |
dc.contributor.alternativeName | 윤소현 | - |
dc.contributor.alternativeName | 이석형 | - |
dc.contributor.alternativeName | 이수의 | - |
dc.contributor.alternativeName | 정미라 | - |
dc.contributor.alternativeName | Sun | - |
dc.contributor.alternativeName | 박영준 | - |
dc.contributor.alternativeName | 정해용 | - |
dc.contributor.alternativeName | 윤석란 | - |
dc.contributor.alternativeName | 최인표 | - |
dc.identifier.bibliographicCitation | Immunology Letters, vol. 141, no. 1, pp. 61-67 | - |
dc.identifier.doi | 10.1016/j.imlet.2011.07.007 | - |
dc.subject.keyword | Differentiation | - |
dc.subject.keyword | IL-22 | - |
dc.subject.keyword | NCR22 | - |
dc.subject.keyword | NK cells | - |
dc.subject.keyword | RORγt | - |
dc.subject.local | differentiation | - |
dc.subject.local | Differentiation | - |
dc.subject.local | IL-22 | - |
dc.subject.local | NCR22 | - |
dc.subject.local | NK cells | - |
dc.subject.local | NK cell | - |
dc.subject.local | RORγt | - |
dc.description.journalClass | Y | - |
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