IL-22 producing NKp46+ innate lymphoid cells can differentiate from hematopoietic precursor cells = 조혈줄기세포로부터 IL-22를 생산하는 innate lymphoid cell의 분화

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dc.contributor.authorM S Kim-
dc.contributor.authorWon Sam Kim-
dc.contributor.authorZ H Piao-
dc.contributor.authorSohyun Yun-
dc.contributor.authorS H Lee-
dc.contributor.authorSu Ui Lee-
dc.contributor.authorM Jeong-
dc.contributor.authorH N Sun-
dc.contributor.authorYoung-Jun Park-
dc.contributor.authorHaiyoung Jung-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorIn Pyo Choi-
dc.date.accessioned2017-04-19T09:25:45Z-
dc.date.available2017-04-19T09:25:45Z-
dc.date.issued2011-
dc.identifier.issn0165-2478-
dc.identifier.uri10.1016/j.imlet.2011.07.007ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10378-
dc.description.abstractThe IL-22 NKp46+ innate lymphoid cells, NCR22 cells, are very important for the early host defense against microbial pathogens. We show here that NCR22 cells were differentiated from Lin-CD127+CD117+ cells that were derived from hematopoietic precursor cells (HPCs) of mouse bone marrow cells. The combination of low concentrations of IL-23 and IL-15 induced differentiation of NCR22 cells from Lin-CD127+CD117+ cells. NCR22 cells expressed a large amount of IL-22 and RORγt, and they had poor cytolytic activity and produced little IFN-γ Lin-CD127+CD117+ cells were very similar to intestinal lamina propria LTi-like cells; both cells dominantly expressed RORγt and IL-22. Meanwhile, Lin-CD127-CD117+ cells that were also derived from HPCs did not express RORγt and IL-22, and they developed into conventional NK cells, not into NCR22 cells. These findings revealed that NCR22 cells can be differentiated from Lin-CD127+CD117+ cells which are derived from HPCs.-
dc.publisherElsevier-
dc.titleIL-22 producing NKp46+ innate lymphoid cells can differentiate from hematopoietic precursor cells = 조혈줄기세포로부터 IL-22를 생산하는 innate lymphoid cell의 분화-
dc.title.alternativeIL-22 producing NKp46+ innate lymphoid cells can differentiate from hematopoietic precursor cells-
dc.typeArticle-
dc.citation.titleImmunology Letters-
dc.citation.number1-
dc.citation.endPage67-
dc.citation.startPage61-
dc.citation.volume141-
dc.contributor.affiliatedAuthorWon Sam Kim-
dc.contributor.affiliatedAuthorSohyun Yun-
dc.contributor.affiliatedAuthorSu Ui Lee-
dc.contributor.affiliatedAuthorYoung-Jun Park-
dc.contributor.affiliatedAuthorHaiyoung Jung-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName김미선-
dc.contributor.alternativeName김원삼-
dc.contributor.alternativeNamePiao-
dc.contributor.alternativeName윤소현-
dc.contributor.alternativeName이석형-
dc.contributor.alternativeName이수의-
dc.contributor.alternativeName정미라-
dc.contributor.alternativeNameSun-
dc.contributor.alternativeName박영준-
dc.contributor.alternativeName정해용-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName최인표-
dc.identifier.bibliographicCitationImmunology Letters, vol. 141, no. 1, pp. 61-67-
dc.identifier.doi10.1016/j.imlet.2011.07.007-
dc.subject.keywordDifferentiation-
dc.subject.keywordIL-22-
dc.subject.keywordNCR22-
dc.subject.keywordNK cells-
dc.subject.keywordRORγt-
dc.subject.localdifferentiation-
dc.subject.localDifferentiation-
dc.subject.localIL-22-
dc.subject.localNCR22-
dc.subject.localNK cells-
dc.subject.localNK cell-
dc.subject.localRORγt-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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