pH-stimuli-responsive near-infrared optical imaging nanoprobe based on poly(γ -glutamic acid)/poly(β-amino ester) nanoparticles = 폴리감마/폴리에스테르 나노입자의 광학 이미징

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Title
pH-stimuli-responsive near-infrared optical imaging nanoprobe based on poly(γ -glutamic acid)/poly(β-amino ester) nanoparticles = 폴리감마/폴리에스테르 나노입자의 광학 이미징
Author(s)
H S Park; J E Lee; M Y Cho; Y W Noh; M H Sung; Haryoung Poo; K S Hong; Y T Lim
Bibliographic Citation
Nanotechnology, vol. 22, no. 46, pp. 465603-465611
Publication Year
2011
Abstract
pH-stimuli-responsive near-infrared optical imaging nanoprobes are designed and synthesized in this study in a facile one-step synthesis process based on the use of the biocompatible and biodegradable polymer poly(γ-glutamic acid) (γ-PGA)/poly(β-amino ester) (PBAE). PBAE has good transfection efficiency and promotes degradation properties under acidic conditions. This pH-responsive degradability can be used for the effective release of encapsulating materials after cellular uptake. As an optical imaging probe, indocyanine green (ICG) is an FDA-approved near-infrared fluorescent dye with a quenching property at a high concentration. In this regard, we focus here on the rapid degradation of PBAE in an acidic environment, in which the nanoparticles are disassembled. This allows the ICG dyes to show enhanced fluorescence signals after being releasing from the particles. We demonstrated this principle in cellular uptake experiments. We expect that the developed pH-stimuli-responsive smart nanoprobes can be applied in intracellular delivery signaling applications.
ISSN
0957-4484
Publisher
IOP Publishing Ltd
DOI
http://dx.doi.org/10.1088/0957-4484/22/46/465603
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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