Neuron-specific expression of Scratch genes during early zebrafish development = 제브라퓌쉬 발생중 Scratch 유전자들의 신경특이적 발현

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Title
Neuron-specific expression of Scratch genes during early zebrafish development = 제브라퓌쉬 발생중 Scratch 유전자들의 신경특이적 발현
Author(s)
T M T Dam; H T Kim; H Y Moon; K S Hwang; Y M Jeong; K H You; Jeong Soo Lee; C H Kim
Bibliographic Citation
Molecules and Cells, vol. 31, no. 5, pp. 471-475
Publication Year
2011
Abstract
Scratch (scrt) genes are neural-specific in mammals, but their homologues have not been well studied in nonmammalian vertebrates. In this report, we isolated three zebrafish scrt genes, scratch1a (scrt1a), scratch1b (scrt1b), and scratch2 (scrt2), which belong to the Snail superfamily of zinc finger transcription factors. Spatiotemporal expression analysis revealed that scrt1a and scrt2 were initially detected in the central nervous system (CNS) during early somitogenesis while scrt1b was first detectable in neuronal clusters in the brain during late somitogenesis. Interestingly, scrt-expressing cells largely overlapped with huC-positive differentiating neurons and partially with neurogenin1-positive neuronal precursor cells. In addition, scrt-expressing cells were dramatically increased in mind bomb, a neurogenic mutant. Taken together, these results suggest that each zebrafish scrt gene is specifically expressed in neuronal cells and may be involved in differentiation of distinct neuronal populations in the vertebrate nervous system.
Keyword
Central nervous systemNeuronal differentiationScratchZebrafish
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.1007/s10059-011-0052-4
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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