Identification and characterization of full-length vps29 gene in five mammalian species

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Identification and characterization of full-length vps29 gene in five mammalian species
Young-Hyun KimSang Je ParkJae Won Huh; Kyeong Min Kim; Sang Rae Lee; K Imakawa; Kyu Tae Chang
Bibliographic Citation
Genes & Genomics, vol. 33, no. 5, pp. 505-512
Publication Year
Retromer is a heteropentameric complex associated with retrograde transport of cargo protein from the endosome to the trans-Golgi network. The mammalian retromer complex consists of three vps genes (vps26, vps35, and vps29) and two sorting nexin genes (snx1 and snx2). Previous studies had reported the protein sorting functions of retromer in the intracellular compartment. However, individual genes of retromer complex have not yet been fully characterized. In this study, we identified full-length vps29 gene in human, crab-eating macaque, mouse, rat, and dog species. Total forty-four novel transcripts of vps29, including two actively expressed major transcripts, were identified by 5′- and 3′-RACE. Comparative analysis indicated that functionally important sites of the vps29 gene were well conserved in the eukaryotic genome. However, two major transcript variants were occurred in the vertebrate genome only. From our results, we assumed that there are many different transcripts variants of vps29 gene and specifically two major transcripts could play important roles in the protein sorting mechanism.
vps29 geneRetromer complexProtein sortingTranscript variants
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Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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