Lidocaine induces endoplasmic reticulum stress-associated apoptosis in Vitro and in Vivo

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dc.contributor.authorD Y Hong-
dc.contributor.authorK Kwon-
dc.contributor.authorK R Lee-
dc.contributor.authorY J Choi-
dc.contributor.authorT W Goo-
dc.contributor.authorKweon Yu-
dc.contributor.authorS W Kim-
dc.contributor.authorO Y Kwon-
dc.date.accessioned2017-04-19T09:25:56Z-
dc.date.available2017-04-19T09:25:56Z-
dc.date.issued2011-
dc.identifier.issn14220067-
dc.identifier.uri10.3390/ijms12117652ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10407-
dc.description.abstractWe demonstrated that upregulation of both gene expression of endoplasmic reticulum (ER) stress chaperones (BiP, calnexin, calreticulin, and PDI) and ER stress sensors (ATF6, IRE1 and PERK) was induced by lidocaine, a local anesthetic, in PC12 cells. In addition to gene regulation, lidocaine also induced typical ER stress phenomena such as ART6 proteolytic cleavage, eIF2 alpha phosphorylation, and XBP1 mRNA splicing. In in vivo experiments, while lidocaine downregulated gene expression of anti-apoptotic factors (Bcl-2 and Bcl-xl), pro-apoptotic factor (Bak and Bax) gene expression was upregulated. Furthermore, lidocaine induced apoptosis, as measured histochemically, and upregulated PARP1, a DNA damage repair enzyme. These results are the first to show that lidocaine induces apoptosis through ER stress in vitro and in vivo.-
dc.publisherMDPI-
dc.titleLidocaine induces endoplasmic reticulum stress-associated apoptosis in Vitro and in Vivo-
dc.title.alternativeLidocaine induces endoplasmic reticulum stress-associated apoptosis in Vitro and in Vivo-
dc.typeArticle-
dc.citation.titleInternational Journal of Molecular Sciences-
dc.citation.number11-
dc.citation.endPage7661-
dc.citation.startPage7652-
dc.citation.volume12-
dc.contributor.affiliatedAuthorKweon Yu-
dc.contributor.alternativeName홍대영-
dc.contributor.alternativeName권기상-
dc.contributor.alternativeName이경용-
dc.contributor.alternativeName최영진-
dc.contributor.alternativeName구태원-
dc.contributor.alternativeName유권-
dc.contributor.alternativeName김승환-
dc.contributor.alternativeName권오유-
dc.identifier.bibliographicCitationInternational Journal of Molecular Sciences, vol. 12, no. 11, pp. 7652-7661-
dc.identifier.doi10.3390/ijms12117652-
dc.subject.keywordApoptosis-
dc.subject.keywordEndoplasmic reticulum (ER) stress-
dc.subject.keywordER chaperone-
dc.subject.keywordER stress sensor-
dc.subject.keywordLidocaine-
dc.subject.localApoptosis-
dc.subject.localEndoplasmic reticulum (ER) stress-
dc.subject.localEndoplasmic reticulum stress-
dc.subject.localER chaperone-
dc.subject.localER stress sensor-
dc.subject.localLidocaine-
dc.description.journalClassY-
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Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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