The N-end rule pathway: emerging functions and molecular principles of substrate recognition

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dc.contributor.authorS M Sriram-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorY T Kwon-
dc.date.accessioned2017-04-19T09:25:57Z-
dc.date.available2017-04-19T09:25:57Z-
dc.date.issued2011-
dc.identifier.issn14710072-
dc.identifier.uri10.1038/nrm3217ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10412-
dc.description.abstractThe N-end rule defines the protein-destabilizing activity of a given amino-terminal residue and its post-translational modification. Since its discovery 25 years ago, the pathway involved in the N-end rule has been thought to target only a limited set of specific substrates of the ubiquitin-proteasome system. Recent studies have provided insights into the components, substrates, functions and structural basis of substrate recognition. The N-end rule pathway is now emerging as a major cellular proteolytic system, in which the majority of proteins are born with or acquire specific N-terminal degradation determinants through protein-specific or global post-translational modifications.-
dc.publisherSpringer-Nature Pub Group-
dc.titleThe N-end rule pathway: emerging functions and molecular principles of substrate recognition-
dc.title.alternativeThe N-end rule pathway: emerging functions and molecular principles of substrate recognition-
dc.typeArticle-
dc.citation.titleNature Reviews Molecular Cell Biology-
dc.citation.number12-
dc.citation.endPage747-
dc.citation.startPage735-
dc.citation.volume12-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.alternativeNameSriram-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName권용태-
dc.identifier.bibliographicCitationNature Reviews Molecular Cell Biology, vol. 12, no. 12, pp. 735-747-
dc.identifier.doi10.1038/nrm3217-
dc.description.journalClassY-
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Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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