Ent-kaur-16-en-19-oic acid, isolated from the roots of Aralia continentalis, induces activation of Nrf2

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dc.contributor.authorJ H Lyu-
dc.contributor.authorG S Lee-
dc.contributor.authorK H Kim-
dc.contributor.authorH W Kim-
dc.contributor.authorS I Cho-
dc.contributor.authorS I Jeong-
dc.contributor.authorH J Kim-
dc.contributor.authorY S Ju-
dc.contributor.authorH K Kim-
dc.contributor.authorR T Sadikot-
dc.contributor.authorJ W Christman-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorM Joo-
dc.date.accessioned2017-04-19T09:25:57Z-
dc.date.available2017-04-19T09:25:57Z-
dc.date.issued2011-
dc.identifier.issn0378-8741-
dc.identifier.uri10.1016/j.jep.2011.08.024ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10415-
dc.description.abstractEthnopharmacological relevance: Excessive inflammation can lead to tissue damage and dysfunction of vital organs. Hence, regulating inflammatory response is a viable therapeutic approach. In Asian countries, various inflammatory diseases have often effectively been treated with herbal remedies including the root extract of Aralia continentalis Kitagawa (Araliaceae). Here, we investigated the effect of kaurenoic acid (ent-kaur-16-en-19-oic acid: KA), a diterpenoid that is extracted from Aralia continentalis Kitagawa root, on inflammation. Materials, methods, and results: Western blot and RT-PCR analyses show that KA induced the nuclear localization of Nrf2 as low as 1 nM in concentration and that KA treatment induced the expression of Nrf2 dependent genes such as GCLC and HO-1. On the other hand, KA did not affect the degradation of cytoplasmic IκB-α, the nuclear localization of RelA (p65), and NF-κB transcriptional activity in RAW264.7 cells treated with endotoxin. Consistent with these data, KA treatment failed to suppress gene expression of representative pro-inflammatory mediators including COX-2, nitric oxide, IL-1β, TNF-α, and IL-12, indicating that KA did not have an important impact on NF-κB activation. Conclusion: Together, these results show that KA was an effective activator of Nrf2, and suggest that the beneficial effects of Aralia continentalis Kitagawa root extract are, at least in part, mediated by activating Nrf2.-
dc.publisherElsevier-
dc.titleEnt-kaur-16-en-19-oic acid, isolated from the roots of Aralia continentalis, induces activation of Nrf2-
dc.title.alternativeEnt-kaur-16-en-19-oic acid, isolated from the roots of Aralia continentalis, induces activation of Nrf2-
dc.typeArticle-
dc.citation.titleJournal of Ethnopharmacology-
dc.citation.number3-
dc.citation.endPage1449-
dc.citation.startPage1442-
dc.citation.volume137-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.alternativeName류지효-
dc.contributor.alternativeName이금산-
dc.contributor.alternativeName김균하-
dc.contributor.alternativeName김형우-
dc.contributor.alternativeName조수인-
dc.contributor.alternativeName정승일-
dc.contributor.alternativeName김홍준-
dc.contributor.alternativeName주영승-
dc.contributor.alternativeName김호경-
dc.contributor.alternativeNameSadikot-
dc.contributor.alternativeNameChristman-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName주명수-
dc.identifier.bibliographicCitationJournal of Ethnopharmacology, vol. 137, no. 3, pp. 1442-1449-
dc.identifier.doi10.1016/j.jep.2011.08.024-
dc.subject.keywordAnti-inflammation-
dc.subject.keywordHerbal treatment-
dc.subject.keywordInflammation-
dc.subject.keywordKaurenoic acid-
dc.subject.keywordNrf2-
dc.subject.localAnti-inflammation-
dc.subject.localAntiinflammation-
dc.subject.localanti-inflammation-
dc.subject.localAnti-Inflammation-
dc.subject.localantiinflammation-
dc.subject.localHerbal treatment-
dc.subject.localInflammation-
dc.subject.localinflammation-
dc.subject.localnflammation-
dc.subject.localKaurenoic acid-
dc.subject.localNRF2-
dc.subject.localNrf-2-
dc.subject.localNrf2-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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